Activator-12-LYPLAL1
General
Type : Triazol, Sulfonamide, Sulfure compound
Chemical_Nomenclature : 5-[(4-chlorophenyl)methylsulfanyl]-2-[(2-methyl-1,3-benzothiazol-6-yl)sulfonyl]-1,2,4-triazol-3-amine
Canonical SMILES : CC1=NC2=C(S1)C=C(C=C2)S(=O)(=O)N3C(=NC(=N3)SCC4=CC=C(C=C4)Cl)N
InChI : InChI=1S\/C17H14ClN5O2S3\/c1-10-20-14-7-6-13(8-15(14)27-10)28(24,25)23-16(19)21-17(22-23)26-9-11-2-4-12(18)5-3-11\/h2-8H,9H2,1H3,(H2,19,21,22)
InChIKey : ZWRKCNIYLNLXEH-UHFFFAOYSA-N
Other name(s) :
MW : 452.0
Formula : C17H14ClN5O2S3
CAS_number :
PubChem : 146020301
UniChem : ZWRKCNIYLNLXEH-UHFFFAOYSA-N
Target
Families : LYsophospholipase_carboxylesterase
Protein : human-LYPLA1, mouse-lypla1
References (1)
| Title : Discovery of small-molecule enzyme activators by activity-based protein profiling - Kok_2020_Nat.Chem.Biol_16_997 |
| Author(s) : Kok BP , Ghimire S , Kim W , Chatterjee S , Johns T , Kitamura S , Eberhardt J , Ogasawara D , Xu J , Sukiasyan A , Kim SM , Godio C , Bittencourt JM , Cameron M , Galmozzi A , Forli S , Wolan DW , Cravatt BF , Boger DL , Saez E |
| Ref : Nat Chemical Biology , 16 :997 , 2020 |
| Abstract : Kok_2020_Nat.Chem.Biol_16_997 |
| ESTHER : Kok_2020_Nat.Chem.Biol_16_997 |
| PubMedSearch : Kok_2020_Nat.Chem.Biol_16_997 |
| PubMedID: 32514184 |
| Gene_locus related to this paper: human-LYPLAL1 |