Bacterial AHL-acylases (acyl homoserine lactonase) (AiiO, AidH) from genus Ochrobactrum and related bacteria are different from previously described AHL-acylases such as PvdQ, QuiP (P.aeriginosa) HacA HacB (P.syringea which belong to Ntn-hydrolase superfamily Czajkowski et al.) and different from AHL-lactonase of B. thuringensis and A. tumefasciens (which are metallo-beta lactamases). AHL-acylase inactivates N-acyl homoserine lactone (AHL) quorum sensing signal molecules (lactonases are also inactivating enzymes). AHL-acylases could be useful for the control of development of infections caused by pathogenic bacteria and their persistence in respective hosts. The three fungi sequences are genes without real introns (horizontal transfer?). There are other N-acyl homoserine lactonase (AiiA) not alpha/beta hydroalses but Metallo-B-lactamases
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12697 Abhydrolase_6
Prints : No Print
EC Number : No EC Number
Structures (6)
Genes Proteins in AHL-acylase family (24)
No fragment of genes
Structures in AHL-acylase family (6)Substrates in AHL-acylase family (4)
Inhibitors in AHL-acylase family (2)
Title : High-resolution structures of AidH complexes provide insights into a novel catalytic mechanism for N-acyl homoserine lactonase - Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82 |
Author(s) : Gao A , Mei GY , Liu S , Wang P , Tang Q , Liu YP , Wen H , An XM , Zhang LQ , Yan XX , Liang DC |
Ref : Acta Crystallographica D Biol Crystallogr , 69 :82 , 2013 |
Abstract : Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82 |
ESTHER : Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82 |
PubMedSearch : Gao_2013_Acta.Crystallogr.D.Biol.Crystallogr_69_82 |
PubMedID: 23275166 |
Gene_locus related to this paper: 9rhiz-d2j2t6 |
Title : Inactivation of AHLs by Ochrobactrum sp. A44 depends on the activity of a novel class of AHL acylase - Czajkowski_2011_Environ.Microbiol.Rep_3_59 |
Author(s) : Czajkowski R , Krzyzanowska D , Karczewska J , Atkinson S , Przysowa J , Lojkowska E , Williams P , Jafra S |
Ref : Environ Microbiol Rep , 3 :59 , 2011 |
Abstract : Czajkowski_2011_Environ.Microbiol.Rep_3_59 |
ESTHER : Czajkowski_2011_Environ.Microbiol.Rep_3_59 |
PubMedSearch : Czajkowski_2011_Environ.Microbiol.Rep_3_59 |
PubMedID: 23761232 |
Gene_locus related to this paper: 9rhiz-d8x182 |
Title : AidH, an alpha\/beta-hydrolase fold family member from an Ochrobactrum sp. strain, is a novel N-acylhomoserine lactonase - Mei_2010_Appl.Environ.Microbiol_76_4933 |
Author(s) : Mei GY , Yan XX , Turak A , Luo ZQ , Zhang LQ |
Ref : Applied Environmental Microbiology , 76 :4933 , 2010 |
Abstract : Mei_2010_Appl.Environ.Microbiol_76_4933 |
ESTHER : Mei_2010_Appl.Environ.Microbiol_76_4933 |
PubMedSearch : Mei_2010_Appl.Environ.Microbiol_76_4933 |
PubMedID: 20525860 |
Gene_locus related to this paper: 9rhiz-d2j2t6 |
Title : Quenching of acyl-homoserine lactone-dependent quorum sensing by enzymatic disruption of signal molecules. - Czajkowski_2009_Acta.Biochim.Pol_56_1 |
Author(s) : Czajkowski R , Jafra S |
Ref : Acta Biochim Pol , 56 :1 , 2009 |
Abstract : Czajkowski_2009_Acta.Biochim.Pol_56_1 |
ESTHER : Czajkowski_2009_Acta.Biochim.Pol_56_1 |
PubMedSearch : Czajkowski_2009_Acta.Biochim.Pol_56_1 |
PubMedID: 19287806 |