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MEST-like

Relationship

Family: MEST-like

Block: X

Parent Family: Epoxide-hydrolase_like

Comment

Mesoderm-specific transcript (Mest) predominantly expressed in mesoderm and its derivatives is also an imprinted gene whose expression is dependent on parental origin and is designated Peg1 (paternally expressed gene-1). Curiously orthologues seem present in vertebrates, few invertebrates (molluscs, ticks, amphioxus) but not in insects or nematodes. Absent in plants and present in a limited number of bacteria

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12697 Abhydrolase_6

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Gene_locus Name Species
9alte-a6f1s3 Marinobacter algicola DG893 Alpha\/beta hydrolase fold protein Marinobacter algicola DG893
9bact-a2a0l9 Microscilla marina ATCC 23134 Alpha\/beta hydrolase fold Microscilla marina ATCC 23134
9bact-c0bke3 Flavobacteria bacterium MS024-2A Alpha\/beta hydrolase fold protein Flavobacteria bacterium MS024-2A
9burk-a6gr44 Limnobacter sp. MED105 Probable epoxide hydrolase Limnobacter sp. MED105
9delt-a6gdj5 Plesiocystis pacifica SIR-1 Probable epoxide hydrolase Plesiocystis pacifica SIR-1
9delt-a6geu6 Plesiocystis pacifica SIR-1 Probable epoxide hydrolase Plesiocystis pacifica SIR-1
9flao-a2u1z3 Polaribacter sp. MED152 Alpha\/beta hydrolase Polaribacter sp. MED152
9flao-a2u1z4 Polaribacter sp. MED152 Alpha\/beta hydrolase Polaribacter sp. MED152
9gamm-a0y5r6 Alteromonadales bacterium TW-7 Hydrolase, alpha\/beta fold family protein Alteromonadales bacterium TW-7
9gamm-a4a7a9 Congregibacter litoralis KT71 Putative uncharacterized protein Congregibacter litoralis KT71
9gamm-b5js73 gamma proteobacterium HTCC5015 Hydrolase, alpha\/beta fold family gamma proteobacterium HTCC5015
9gamm-b7rtz4 marine gamma proteobacterium HTCC2148 Hydrolase, alpha\/beta fold family, putative marine gamma proteobacterium HTCC2148
9gamm-b7rx32 marine gamma proteobacterium HTCC2148 Hydrolase, alpha\/beta fold family, putative marine gamma proteobacterium HTCC2148
9gamm-b8kpn8 gamma proteobacterium NOR5-3 Putative uncharacterized protein gamma proteobacterium NOR5-3
9gamm-q1yua4 marine gamma proteobacterium HTCC2207 hydrolase, alpha\/beta fold family protein marine gamma proteobacterium HTCC2207
9rhob-a3uen6 Oceanicaulis sp. HTCC2633 Hydrolase, alpha\/beta fold family protein Oceanicaulis sp. HTCC2633
9sphn-a3wbi6 Erythrobacter sp. NAP1 Hydrolase, alpha\/beta fold family protein Erythrobacter sp. NAP1
9sphn-q2n9r2 Erythrobacter litoralis HTCC2594 probable epoxide hydrolase Erythrobacter litoralis HTCC2594
ailme-d2gwu1 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
bovin-q2hjm9 Bos taurus (Bovine) mesoderm-specific transcript Paternally-expressed gene 1 peg1 (fragment) Bos taurus
brafl-c3ylp9 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3ylq0 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3ylq1 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
bufbg-a9xfz1 Bufo bufo gargarizans (Asian toad) Mesoderm-specific transcript protein Bufo bufo gargarizans
danre-PEG1 Danio rerio (Zebrafish) (Zebra danio) epoxide hydrolase (EC 3.3.2.3)mesoderm specific transcript Danio rerio
fugru-MEST Fugu rubripes (Japanese pufferfish) (Takifugu rubripes) epoxide hydrolase (EC 3.3.2.3) Fugu rubripes
human-MEST Homo sapiens (Human) MEST mesoderm-specific transcript Homo sapiens
ixosc-b7pzn9 Ixodes scapularis (Black-legged tick) (Deer tick) Soluble epoxide hydrolase, putative Ixodes scapularis
lepba-b0sc63 Leptospira biflexa serovar Patoc (strain Patoc 1 \/ Ames\; Patoc 1 \/ ATCC 23582 Paris) Hydrolase or Acyltransferase Leptospira biflexa serovar Patoc
lepba-b0sct4 Leptospira biflexa serovar Patoc (strains Patoc 1 \/ Ames\; Patoc 1 \/ ATCC 23582 Paris) Hydrolase or Acyltransferase Leptospira biflexa serovar Patoc
lepin-LA3788 Leptospira interrogans alpha\/beta hydrolase Leptospira interrogans
macfa-q4r3p4 Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey) transcript homolog (mouse) (mest),transcript variant 1 Macaca fascicularis
marav-a1u781 Marinobacter hydrocarbonoclasticus VT8 Alpha\/beta hydrolase fold protein Marinobacter hydrocarbonoclasticus VT8
mouse-MEST Mus musculus Mouse and Mus musculus molossinus (Japanese house mouse) Mesoderm-specific transcript protein Mus musculus
myca9-b1mjl6 Mycobacterium abscessus (strain ATCC 19977 \/ DSM 44196) Putative hydrolase, alpha\/beta fold Mycobacterium abscessus
mycmm-b2hsy0 Mycobacterium marinum (strain ATCC BAA-535 \/ M) Hydrolase Mycobacterium marinum
mycs2-a0qw20 Mycobacterium smegmatis (strain ATCC 700084 \/ mc(2)155) alpha\/beta hydrolase fold Mycobacterium smegmatis
myctu-LIPS Mycobacterium tuberculosis, Mycobacterium bovis, Epoxide hydrolase mesT Rv3176c MT3265 LIPS mesT (Epoxide hydratase) (Arene-oxide hydratase) Mycobacterium tuberculosis
myctu-Y1834 Mycobacterium tuberculosis\; Mycobacterium bovis, Putative hydrolase YI34 Rv1834 MT1882 Mycobacterium tuberculosis
mycua-a0psi3 Mycobacterium ulcerans (strain Agy99) Hydrolase Mycobacterium ulcerans
nemve-a7sj77 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
pig-b7s817 Sus scrofa (Pig) MEST Mesoderm-specific transcript Sus scrofa
psea6-q15qg7 Pseudoalteromonas atlantica (strain T6c \/ BAA-1087) Alpha\/beta hydrolase fold familiy Pseudoalteromonas atlantica
pseae-PA3429 Pseudomonas aeruginosa (strains PA01\; PA7\; 2192\; C3719\; LESB58\; UCBPP-PA14) PA3429 probable epoxide hydrolase Pseudomonas aeruginosa
psee4-q1i4z6 Pseudomonas entomophila (strain L48) Putative hydrolase, alpha\/beta fold family Pseudomonas entomophila
psef5-q4ki42 Pseudomonas fluorescens (strain Pf-5 \/ ATCC BAA-477) hydrolase, alpha\/beta fold family Pseudomonas fluorescens
psefs-c3k1v7 Pseudomonas fluorescens (strain SBW25) Putative hydrolase Pseudomonas fluorescens
psemy-a4xxg7 Pseudomonas mendocina (strain ymp) Alpha\/beta hydrolase fold protein Pseudomonas mendocina
psepf-q3khw1 Pseudomonas fluorescens (strain PfO-1) alpha\/beta hydrolase fold Pseudomonas fluorescens
psepu-PP4624 Pseudomonas putida (strains KT2440\; F1 \/ ATCC 700007\; GB-1) hydrolase, alpha\/beta fold family Ppueh Pseudomonas putida
psepw-b1j387 Pseudomonas putida (strain W619) Alpha\/beta hydrolase fold Pseudomonas putida
pseu5-a4vgg6 Pseudomonas stutzeri (strain A1501) Probable epoxide hydrolase Pseudomonas stutzeri
ratno-q6p5p5 Rattus norvegicus (Rat) Mesoderm-specific transcript homolog protein Rattus norvegicus
rhocs-b6isd8 Rhodospirillum centenum (strain ATCC 51521 \/ SW) Hydrolase, alpha Rhodospirillum centenum
shefn-q07x13 Shewanella frigidimarina (strain NCIMB 400) Alpha\/beta hydrolase fold Shewanella frigidimarina
triad-b3rw12 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens
xenla-a5d8n0 Xenopus laevis (African clawed frog) LOC100049753 protein Xenopus laevis
xentr-q6dj56 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) mesoderm specific transcript homolog Xenopus tropicalis

Gene_locus_frgt Name Species
triad-b3ruy0 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens
triad-b3ruy1 Trichoplax adhaerens (Trichoplax reptans) Putative uncharacterized protein Trichoplax adhaerens

References (14)

Title : Mesoderm-specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy - Prudovsky_2018_J.Cell.Biochem_119_2636
Author(s) : Prudovsky I , Anunciado-Koza RP , Jacobs CG , Kacer D , Siviski ME , Koza RA
Ref : Journal of Cellular Biochemistry , 119 :2636 , 2018
Abstract :
PubMedSearch : Prudovsky_2018_J.Cell.Biochem_119_2636
PubMedID: 29058774
Gene_locus related to this paper: mouse-MEST

Title : Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet - Anunciado-Koza_2016_Biochimie_124_134
Author(s) : Anunciado-Koza RP , Higgins DC , Koza RA
Ref : Biochimie , 124 :134 , 2016
Abstract :
PubMedSearch : Anunciado-Koza_2016_Biochimie_124_134
PubMedID: 26005096
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism - Himes_2015_Placenta_36_389
Author(s) : Himes KP , Young A , Koppes E , Stolz D , Barak Y , Sadovsky Y , Chaillet JR
Ref : Placenta , 36 :389 , 2015
Abstract :
PubMedSearch : Himes_2015_Placenta_36_389
PubMedID: 25662615
Gene_locus related to this paper: human-MEST

Title : Identification of Mest\/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions - Voigt_2015_Genes.Nutr_10_477
Author(s) : Voigt A , Ribot J , Sabater AG , Palou A , Bonet ML , Klaus S
Ref : Genes Nutr , 10 :477 , 2015
Abstract :
PubMedSearch : Voigt_2015_Genes.Nutr_10_477
PubMedID: 26143179

Title : Variable imprinting of the MEST gene in human preimplantation embryos - Huntriss_2013_Eur.J.Hum.Genet_21_40
Author(s) : Huntriss JD , Hemmings KE , Hinkins M , Rutherford AJ , Sturmey RG , Elder K , Picton HM
Ref : Eur J Hum Genet , 21 :40 , 2013
Abstract :
PubMedSearch : Huntriss_2013_Eur.J.Hum.Genet_21_40
PubMedID: 22763377
Gene_locus related to this paper: human-MEST

Title : Mest\/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation - Jung_2011_Biochem.J_436_263
Author(s) : Jung H , Lee SK , Jho EH
Ref : Biochemical Journal , 436 :263 , 2011
Abstract :
PubMedSearch : Jung_2011_Biochem.J_436_263
PubMedID: 21375506
Gene_locus related to this paper: human-MEST

Title : Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance - Nikonova_2008_FASEB.J_22_3925
Author(s) : Nikonova L , Koza RA , Mendoza T , Chao PM , Curley JP , Kozak LP
Ref : FASEB Journal , 22 :3925 , 2008
Abstract :
PubMedSearch : Nikonova_2008_FASEB.J_22_3925
PubMedID: 18644838
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32 - Nakabayashi_2002_Hum.Mol.Genet_11_1743
Author(s) : Nakabayashi K , Bentley L , Hitchins MP , Mitsuya K , Meguro M , Minagawa S , Bamforth JS , Stanier P , Preece M , Weksberg R , Oshimura M , Moore GE , Scherer SW
Ref : Hum Mol Genet , 11 :1743 , 2002
Abstract :
PubMedSearch : Nakabayashi_2002_Hum.Mol.Genet_11_1743
PubMedID: 12095916
Gene_locus related to this paper: mouse-MEST

Title : Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest - Lefebvre_1998_Nat.Genet_20_163
Author(s) : Lefebvre L , Viville S , Barton SC , Ishino F , Keverne EB , Surani MA
Ref : Nat Genet , 20 :163 , 1998
Abstract :
PubMedSearch : Lefebvre_1998_Nat.Genet_20_163
PubMedID: 9771709
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Monoallelic expression of human PEG1\/MEST is paralleled by parent-specific methylation in fetuses - Riesewijk_1997_Genomics_42_236
Author(s) : Riesewijk AM , Hu L , Schulz U , Tariverdian G , Hoglund P , Kere J , Ropers HH , Kalscheuer VM
Ref : Genomics , 42 :236 , 1997
Abstract :
PubMedSearch : Riesewijk_1997_Genomics_42_236
PubMedID: 9192843
Gene_locus related to this paper: human-MEST

Title : Genomic structure and parent-of-origin-specific methylation of Peg1 - Lefebvre_1997_Hum.Mol.Genet_6_1907
Author(s) : Lefebvre L , Viville S , Barton SC , Ishino F , Surani MA
Ref : Hum Mol Genet , 6 :1907 , 1997
Abstract :
PubMedSearch : Lefebvre_1997_Hum.Mol.Genet_6_1907
PubMedID: 9302270
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Genomic imprinting and chromosomal localization of the human MEST gene - Nishita_1996_Genomics_36_539
Author(s) : Nishita Y , Yoshida I , Sado T , Takagi N
Ref : Genomics , 36 :539 , 1996
Abstract :
PubMedSearch : Nishita_1996_Genomics_36_539
PubMedID: 8884280
Gene_locus related to this paper: human-MEST

Title : Peg1\/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization - Kaneko-Ishino_1995_Nat.Genet_11_52
Author(s) : Kaneko-Ishino T , Kuroiwa Y , Miyoshi N , Kohda T , Suzuki R , Yokoyama M , Viville S , Barton SC , Ishino F , Surani MA
Ref : Nat Genet , 11 :52 , 1995
Abstract :
PubMedSearch : Kaneko-Ishino_1995_Nat.Genet_11_52
PubMedID: 7550314
Gene_locus related to this paper: mouse-MEST

Title : A novel mesoderm-specific cDNA isolated from a mouse embryonal carcinoma cell line -
Author(s) : Sado T , Nakajima N , Tada M , Takagi N
Ref : Dev Growth Differ , 35 :551 , 1993
PubMedID:
Gene_locus related to this paper: human-MEST , mouse-MEST