1. Home
  2. Gene Locus
  3. human-MEST

human-MEST

Homo sapiens (Human) MEST mesoderm-specific transcript

Comment

Mesoderm-specific transcript (Mest) predominantly expressed in mesoderm and its derivatives is also an imprinted gene whose expression is dependent on parental origin and is designated Peg1 (paternally expressed gene-1). Identification and characterization of an imprinted antisense RNART (MESTIT1) in the human MEST locus on chromosome 7q32 PubMed 12095916. Mest is involved in the modulation of adipose tissue expansion. Mest is also highly expressed in the developing and adult brain

Relationship

Family : MEST-like

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MVRRDRLRRM REWWVQVGLL AVPLLAAYLH IPPPQLSPAL HSWKSSGKFF TYKGLRIFYQ DSVGVVGSPE IVVLLHGFPT SSYDWYKIWK GLTLRFHRVI ALDFLGFGFS DKPRPHHYSI FEQASIVEAL LRHLGLQNRR INLLSHDYGD IVAQELLYRY KQNRSGRHTI KSLCLSNGGI FPETHRPLLL QKLLKDGGVL SPILTRLMNF FVFSRGLTPV FGPYTRPSES ELWDMWAGIR NNDGNLVIDS LLQYINQRKK FRRRWVGALA SVTIPIHFIY GPLDPVNPYP EFLELYRKTL PRSTVSILDD HISHYPQLED PMGFLNAYMG FINSF

References (25)

Title : Increased spontaneous physical activity in female MEST-deficient mice protects against diet-induced obesity - Anunciado-Koza_2025_Front.Endocrinol_16_
Author(s) : Anunciado-Koza RVP , Martinez ME , DeMambro V , Hernandez A , Koza RA
Ref : Frontiers in Endocrinology , 16 : , 2025
Abstract :
PubMedSearch : Anunciado-Koza_2025_Front.Endocrinol_16_
PubMedID:
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Mesoderm-specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy - Prudovsky_2018_J.Cell.Biochem_119_2636
Author(s) : Prudovsky I , Anunciado-Koza RP , Jacobs CG , Kacer D , Siviski ME , Koza RA
Ref : Journal of Cellular Biochemistry , 119 :2636 , 2018
Abstract :
PubMedSearch : Prudovsky_2018_J.Cell.Biochem_119_2636
PubMedID: 29058774
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Defective neuronal migration and inhibition of bipolar to multipolar transition of migrating neural cells by Mesoderm-Specific Transcript, Mest, in the developing mouse neocortex - Ji_2017_Neurosci_355_126
Author(s) : Ji L , Bishayee K , Sadra A , Choi S , Choi W , Moon S , Jho EH , Huh SO
Ref : Neuroscience , 355 :126 , 2017
Abstract :
PubMedSearch : Ji_2017_Neurosci_355_126
PubMedID: 28501506
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet - Anunciado-Koza_2016_Biochimie_124_134
Author(s) : Anunciado-Koza RP , Higgins DC , Koza RA
Ref : Biochimie , 124 :134 , 2016
Abstract :
PubMedSearch : Anunciado-Koza_2016_Biochimie_124_134
PubMedID: 26005096
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Mest\/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset - Mesman_2016_Front.Mol.Neurosci_9_166
Author(s) : Mesman S , van Hooft JA , Smidt MP
Ref : Front Mol Neurosci , 9 :166 , 2016
Abstract :
PubMedSearch : Mesman_2016_Front.Mol.Neurosci_9_166
PubMedID: 28133444
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism - Himes_2015_Placenta_36_389
Author(s) : Himes KP , Young A , Koppes E , Stolz D , Barak Y , Sadovsky Y , Chaillet JR
Ref : Placenta , 36 :389 , 2015
Abstract :
PubMedSearch : Himes_2015_Placenta_36_389
PubMedID: 25662615
Gene_locus related to this paper: human-MEST

Title : Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation - Karbiener_2015_Int.J.Obes.(Lond)_39_1733
Author(s) : Karbiener M , Glantschnig C , Pisani DF , Laurencikiene J , Dahlman I , Herzig S , Amri EZ , Scheideler M
Ref : Int J Obes (Lond) , 39 :1733 , 2015
Abstract :
PubMedSearch : Karbiener_2015_Int.J.Obes.(Lond)_39_1733
PubMedID: 26119994
Gene_locus related to this paper: human-MEST

Title : Identification of Mest\/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions - Voigt_2015_Genes.Nutr_10_477
Author(s) : Voigt A , Ribot J , Sabater AG , Palou A , Bonet ML , Klaus S
Ref : Genes Nutr , 10 :477 , 2015
Abstract :
PubMedSearch : Voigt_2015_Genes.Nutr_10_477
PubMedID: 26143179
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Variable imprinting of the MEST gene in human preimplantation embryos - Huntriss_2013_Eur.J.Hum.Genet_21_40
Author(s) : Huntriss JD , Hemmings KE , Hinkins M , Rutherford AJ , Sturmey RG , Elder K , Picton HM
Ref : Eur J Hum Genet , 21 :40 , 2013
Abstract :
PubMedSearch : Huntriss_2013_Eur.J.Hum.Genet_21_40
PubMedID: 22763377
Gene_locus related to this paper: human-MEST

Title : Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development - Itoh_2012_J.Biol.Chem_287_13859
Author(s) : Itoh M , Tahimic CG , Ide S , Otsuki A , Sasaoka T , Noguchi S , Oshimura M , Goto Y , Kurimasa A
Ref : Journal of Biological Chemistry , 287 :13859 , 2012
Abstract :
PubMedSearch : Itoh_2012_J.Biol.Chem_287_13859
PubMedID: 22375006
Gene_locus related to this paper: human-MEST

Title : Mest\/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation - Jung_2011_Biochem.J_436_263
Author(s) : Jung H , Lee SK , Jho EH
Ref : Biochemical Journal , 436 :263 , 2011
Abstract :
PubMedSearch : Jung_2011_Biochem.J_436_263
PubMedID: 21375506
Gene_locus related to this paper: human-MEST

Title : Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation - Koza_2009_Epigenetics_4_512
Author(s) : Koza RA , Rogers P , Kozak LP
Ref : Epigenetics , 4 :512 , 2009
Abstract :
PubMedSearch : Koza_2009_Epigenetics_4_512
PubMedID: 19875931
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance - Nikonova_2008_FASEB.J_22_3925
Author(s) : Nikonova L , Koza RA , Mendoza T , Chao PM , Curley JP , Kozak LP
Ref : FASEB Journal , 22 :3925 , 2008
Abstract :
PubMedSearch : Nikonova_2008_FASEB.J_22_3925
PubMedID: 18644838
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : The full-ORF clone resource of the German cDNA Consortium - Bechtel_2007_BMC.Genomics_8_399
Author(s) : Bechtel S , Rosenfelder H , Duda A , Schmidt CP , Ernst U , Wellenreuther R , Mehrle A , Schuster C , Bahr A , Blocker H , Heubner D , Hoerlein A , Michel G , Wedler H , Kohrer K , Ottenwalder B , Poustka A , Wiemann S , Schupp I
Ref : BMC Genomics , 8 :399 , 2007
Abstract :
PubMedSearch : Bechtel_2007_BMC.Genomics_8_399
PubMedID: 17974005
Gene_locus related to this paper: human-AFMID , human-MEST , human-TMCO4

Title : Peg1\/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner - Kamei_2007_FEBS.Lett_581_91
Author(s) : Kamei Y , Suganami T , Kohda T , Ishino F , Yasuda K , Miura S , Ezaki O , Ogawa Y
Ref : FEBS Letters , 581 :91 , 2007
Abstract :
PubMedSearch : Kamei_2007_FEBS.Lett_581_91
PubMedID: 17182038
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Mest\/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size - Takahashi_2005_Am.J.Physiol.Endocrinol.Metab_288_E117
Author(s) : Takahashi M , Kamei Y , Ezaki O
Ref : American Journal of Physiology Endocrinol Metab , 288 :E117 , 2005
Abstract :
PubMedSearch : Takahashi_2005_Am.J.Physiol.Endocrinol.Metab_288_E117
PubMedID: 15353408
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
Abstract :
PubMedSearch : Ota_2004_Nat.Genet_36_40
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53 , human-cb069

Title : The DNA sequence of human chromosome 7 - Hillier_2003_Nature_424_157
Author(s) : Hillier LW , Fulton RS , Fulton LA , Graves TA , Pepin KH , Wagner-McPherson C , Layman D , Maas J , Jaeger S , Walker R , Wylie K , Sekhon M , Becker MC , O'Laughlin MD , Schaller ME , Fewell GA , Delehaunty KD , Miner TL , Nash WE , Cordes M , Du H , Sun H , Edwards J , Bradshaw-Cordum H , Ali J , Andrews S , Isak A , Vanbrunt A , Nguyen C , Du F , Lamar B , Courtney L , Kalicki J , Ozersky P , Bielicki L , Scott K , Holmes A , Harkins R , Harris A , Strong CM , Hou S , Tomlinson C , Dauphin-Kohlberg S , Kozlowicz-Reilly A , Leonard S , Rohlfing T , Rock SM , Tin-Wollam AM , Abbott A , Minx P , Maupin R , Strowmatt C , Latreille P , Miller N , Johnson D , Murray J , Woessner JP , Wendl MC , Yang SP , Schultz BR , Wallis JW , Spieth J , Bieri TA , Nelson JO , Berkowicz N , Wohldmann PE , Cook LL , Hickenbotham MT , Eldred J , Williams D , Bedell JA , Mardis ER , Clifton SW , Chissoe SL , Marra MA , Raymond C , Haugen E , Gillett W , Zhou Y , James R , Phelps K , Iadanoto S , Bubb K , Simms E , Levy R , Clendenning J , Kaul R , Kent WJ , Furey TS , Baertsch RA , Brent MR , Keibler E , Flicek P , Bork P , Suyama M , Bailey JA , Portnoy ME , Torrents D , Chinwalla AT , Gish WR , Eddy SR , McPherson JD , Olson MV , Eichler EE , Green ED , Waterston RH , Wilson RK
Ref : Nature , 424 :157 , 2003
Abstract :
PubMedSearch : Hillier_2003_Nature_424_157
PubMedID: 12853948
Gene_locus related to this paper: human-ABHD11 , human-ACHE , human-CPVL , human-DPP6 , human-MEST

Title : Isoform-specific imprinting of the human PEG1\/MEST gene -
Author(s) : Kosaki K , Kosaki R , Craigen WJ , Matsuo N
Ref : American Journal of Human Genetics , 66 :309 , 2000
PubMedID: 10631159
Gene_locus related to this paper: human-MEST

Title : Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest - Lefebvre_1998_Nat.Genet_20_163
Author(s) : Lefebvre L , Viville S , Barton SC , Ishino F , Keverne EB , Surani MA
Ref : Nat Genet , 20 :163 , 1998
Abstract :
PubMedSearch : Lefebvre_1998_Nat.Genet_20_163
PubMedID: 9771709
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Monoallelic expression of human PEG1\/MEST is paralleled by parent-specific methylation in fetuses - Riesewijk_1997_Genomics_42_236
Author(s) : Riesewijk AM , Hu L , Schulz U , Tariverdian G , Hoglund P , Kere J , Ropers HH , Kalscheuer VM
Ref : Genomics , 42 :236 , 1997
Abstract :
PubMedSearch : Riesewijk_1997_Genomics_42_236
PubMedID: 9192843
Gene_locus related to this paper: human-MEST

Title : Human PEG1\/MEST, an imprinted gene on chromosome 7 - Kobayashi_1997_Hum.Mol.Genet_6_781
Author(s) : Kobayashi S , Kohda T , Miyoshi N , Kuroiwa Y , Aisaka K , Tsutsumi O , Kaneko-Ishino T , Ishino F
Ref : Hum Mol Genet , 6 :781 , 1997
Abstract :
PubMedSearch : Kobayashi_1997_Hum.Mol.Genet_6_781
PubMedID: 9158153
Gene_locus related to this paper: human-MEST

Title : Genomic structure and parent-of-origin-specific methylation of Peg1 - Lefebvre_1997_Hum.Mol.Genet_6_1907
Author(s) : Lefebvre L , Viville S , Barton SC , Ishino F , Surani MA
Ref : Hum Mol Genet , 6 :1907 , 1997
Abstract :
PubMedSearch : Lefebvre_1997_Hum.Mol.Genet_6_1907
PubMedID: 9302270
Gene_locus related to this paper: human-MEST , mouse-MEST

Title : Genomic imprinting and chromosomal localization of the human MEST gene - Nishita_1996_Genomics_36_539
Author(s) : Nishita Y , Yoshida I , Sado T , Takagi N
Ref : Genomics , 36 :539 , 1996
Abstract :
PubMedSearch : Nishita_1996_Genomics_36_539
PubMedID: 8884280
Gene_locus related to this paper: human-MEST

Title : A novel mesoderm-specific cDNA isolated from a mouse embryonal carcinoma cell line -
Author(s) : Sado T , Nakajima N , Tada M , Takagi N
Ref : Dev Growth Differ , 35 :551 , 1993
PubMedID:
Gene_locus related to this paper: human-MEST , mouse-MEST