Steryl_acetyl_hydrolase

Relationship

Family: Steryl_acetyl_hydrolase

Block: H

Parent Family: No family

Comment

Sterol homeostasis in eukaryotic cells relies on the reciprocal interconversion of free sterols and steryl esters. In Saccharomyces cerevisiae (Baker's yeast) sterol acetylation requires the acetyltransferase Atf2, whereas deacetylation requires Say1, a membrane-anchored deacetylase with a putative active site in the ER lumen. Lack of Say1 results in the secretion of acetylated sterols into the culture medium, indicating that the substrate specificity of Say1 determines whether acetylated sterols are secreted from the cells or whether they are deacetylated and retained. In S. cerevisiae cells lacking Say1 or Atf2 are sensitive against the plant-derived allylbenzene eugenol and both Say1 and Atf2 affect pregnenolone toxicity, indicating that lipid acetylation acts as a detoxification pathway (old DUF2424)

Database

Interpro : IPR019436 Steryl_acetyl_hydrolase Say1-like

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF10340 Say1_Mug180

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Steryl_acetyl_hydrolase family (64)

Fragments of genes in Steryl_acetyl_hydrolase family (1)

No fragment of genes

Substrates in Steryl_acetyl_hydrolase family (1)

No Inhibitor

References (1)

Title : An acetylation\/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae - Tiwari_2007_EMBO.J_26_5109
Author(s) : Tiwari R , Koffel R , Schneiter R
Ref : EMBO Journal , 26 :5109 , 2007
PubMedID: 18034159
Gene_locus related to this paper: yeast-SAY1