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Family Report for: ABHD17-depalmitoylase

ABHD17-depalmitoylase



Relationship
Block X
Parent Family : Hydrolase_4

Comment
ABHD17 proteins are protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization (Lin and Conibear 2015) They are probably themselves palmitoylated. ABHD17A, 17B, and 17C, are identified as the physiological PSD-95 (the most abundant postsynaptic density scaffolding protein) depalmitoylating enzymes in neurones (Yokoi et al.). The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. They belong to a closely related family: LYsophospholipase_carboxylesterase

Database
Sequences
Interpro
|
IPR022742 (Hydrolase_4 Serine aminopeptidase, S33)
PIRSF
|
Pdoc
|
PFam
|
PF12146 (Hydrolase_4)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
7 more
    Title: ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
    Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM and Cravatt BF <8 more author(s)>
    Ref: Nat Chemical Biology, :, 2021 : PubMed

            

    Title: Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation
    Suciu RM, Luvaga IK, Hazeen A, Weerasooriya C, Richardson SK, Firestone AJ, Shannon K, Howell AR, Cravatt BF
    Ref: Bioorganic & Medicinal Chemistry Lett, 53:128414, 2021 : PubMed

            

    Title: Site specific deacylation by ABHD17a controls BK channel splice variant activity
    McClafferty H, Runciman H, Shipston MJ
    Ref: Journal of Biological Chemistry, 295:16487, 2020 : PubMed

            

Other Papers


No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in ABHD17-depalmitoylase family (67)

Fragments of genes in ABHD17-depalmitoylase family (1)

Substrates of some enzymes in the ABHD17-depalmitoylase family (1)

Inhibitors of some enzymes in the ABHD17-depalmitoylase family (10)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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