| Title : In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer - Decker_2025_bioRxiv__ |
| Author(s) : Decker M , Huang BJ , Ware T , Boone C , Tang M , Ybarra J , Ballapuram AC , Taran KA , Chen PY , Amendariz M , Leung CJ , Harris M , Tjoa K , Hongo H , Abelson S , Rivera J , Ngo N , Herbst DM , Suciu RM , Guijas C , Sedighi K , Andalis T , Roche E , Xie B , Liu Y , Smith CC , Stieglitz E , Niphakis MJ , Cravatt BF , Shannon K |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Decker_2025_bioRxiv__ |
| PubMedID: 40166265 |
| Title : In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer - Decker_2025_bioRxiv__ |
| Author(s) : Decker M , Huang BJ , Ware T , Boone C , Tang M , Ybarra J , Ballapuram AC , Taran KA , Chen PY , Amendariz M , Leung CJ , Harris M , Tjoa K , Hongo H , Abelson S , Rivera J , Ngo N , Herbst DM , Suciu RM , Guijas C , Sedighi K , Andalis T , Roche E , Xie B , Liu Y , Smith CC , Stieglitz E , Niphakis MJ , Cravatt BF , Shannon K |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Decker_2025_bioRxiv__ |
| PubMedID: 40166265 |
| Title : In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer - Decker_2025_bioRxiv__ |
| Author(s) : Decker M , Huang BJ , Ware T , Boone C , Tang M , Ybarra J , Ballapuram AC , Taran KA , Chen PY , Amendariz M , Leung CJ , Harris M , Tjoa K , Hongo H , Abelson S , Rivera J , Ngo N , Herbst DM , Suciu RM , Guijas C , Sedighi K , Andalis T , Roche E , Xie B , Liu Y , Smith CC , Stieglitz E , Niphakis MJ , Cravatt BF , Shannon K |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Decker_2025_bioRxiv__ |
| PubMedID: 40166265 |
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation - Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| Author(s) : Suciu RM , Luvaga IK , Hazeen A , Weerasooriya C , Richardson SK , Firestone AJ , Shannon K , Howell AR , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 53 :128414 , 2021 |
| Abstract : |
| PubMedSearch : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| PubMedID: 34666187 |
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation - Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| Author(s) : Suciu RM , Luvaga IK , Hazeen A , Weerasooriya C , Richardson SK , Firestone AJ , Shannon K , Howell AR , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 53 :128414 , 2021 |
| Abstract : |
| PubMedSearch : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| PubMedID: 34666187 |
| Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__ |
| Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF |
| Ref : Nat Chemical Biology , : , 2021 |
| Abstract : |
| PubMedSearch : Remsberg_2021_Nat.Chem.Biol__ |
| PubMedID: 33927411 |
| Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C |
| Title : Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation - Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| Author(s) : Suciu RM , Luvaga IK , Hazeen A , Weerasooriya C , Richardson SK , Firestone AJ , Shannon K , Howell AR , Cravatt BF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 53 :128414 , 2021 |
| Abstract : |
| PubMedSearch : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414 |
| PubMedID: 34666187 |
| Title : Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator - Mizrak_2020_Cell.Rep_31_107805 |
| Author(s) : Mizrak D , Bayin NS , Yuan J , Liu Z , Suciu RM , Niphakis MJ , Ngo N , Lum KM , Cravatt BF , Joyner AL , Sims PA |
| Ref : Cell Rep , 31 :107805 , 2020 |
| Abstract : |
| PubMedSearch : Mizrak_2020_Cell.Rep_31_107805 |
| PubMedID: 32579931 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator - Mizrak_2020_Cell.Rep_31_107805 |
| Author(s) : Mizrak D , Bayin NS , Yuan J , Liu Z , Suciu RM , Niphakis MJ , Ngo N , Lum KM , Cravatt BF , Joyner AL , Sims PA |
| Ref : Cell Rep , 31 :107805 , 2020 |
| Abstract : |
| PubMedSearch : Mizrak_2020_Cell.Rep_31_107805 |
| PubMedID: 32579931 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice - Zambetti_2020_Blood_135_1772 |
| Author(s) : Zambetti NA , Firestone AJ , Remsberg JR , Huang BJ , Wong JC , Long AM , Predovic M , Suciu RM , Inguva A , Kogan SC , Haigis KM , Cravatt BF , Shannon K |
| Ref : Blood , 135 :1772 , 2020 |
| Abstract : |
| PubMedSearch : Zambetti_2020_Blood_135_1772 |
| PubMedID: 32219446 |
| Title : Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator - Mizrak_2020_Cell.Rep_31_107805 |
| Author(s) : Mizrak D , Bayin NS , Yuan J , Liu Z , Suciu RM , Niphakis MJ , Ngo N , Lum KM , Cravatt BF , Joyner AL , Sims PA |
| Ref : Cell Rep , 31 :107805 , 2020 |
| Abstract : |
| PubMedSearch : Mizrak_2020_Cell.Rep_31_107805 |
| PubMedID: 32579931 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice - Zambetti_2020_Blood_135_1772 |
| Author(s) : Zambetti NA , Firestone AJ , Remsberg JR , Huang BJ , Wong JC , Long AM , Predovic M , Suciu RM , Inguva A , Kogan SC , Haigis KM , Cravatt BF , Shannon K |
| Ref : Blood , 135 :1772 , 2020 |
| Abstract : |
| PubMedSearch : Zambetti_2020_Blood_135_1772 |
| PubMedID: 32219446 |
| Title : Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice - Zambetti_2020_Blood_135_1772 |
| Author(s) : Zambetti NA , Firestone AJ , Remsberg JR , Huang BJ , Wong JC , Long AM , Predovic M , Suciu RM , Inguva A , Kogan SC , Haigis KM , Cravatt BF , Shannon K |
| Ref : Blood , 135 :1772 , 2020 |
| Abstract : |
| PubMedSearch : Zambetti_2020_Blood_135_1772 |
| PubMedID: 32219446 |
| Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398 |
| Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P |
| Ref : Nature , 571 :398 , 2019 |
| Abstract : |
| PubMedSearch : Pentinmikko_2019_Nature_571_398 |
| PubMedID: 31292548 |
| Gene_locus related to this paper: human-NOTUM , mouse-notum |
| Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398 |
| Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P |
| Ref : Nature , 571 :398 , 2019 |
| Abstract : |
| PubMedSearch : Pentinmikko_2019_Nature_571_398 |
| PubMedID: 31292548 |
| Gene_locus related to this paper: human-NOTUM , mouse-notum |
| Title : Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium - Pentinmikko_2019_Nature_571_398 |
| Author(s) : Pentinmikko N , Iqbal S , Mana M , Andersson S , Cognetta AB, 3rd , Suciu RM , Roper J , Luopajarvi K , Markelin E , Gopalakrishnan S , Smolander OP , Naranjo S , Saarinen T , Juuti A , Pietilainen K , Auvinen P , Ristimaki A , Gupta N , Tammela T , Jacks T , Sabatini DM , Cravatt BF , Yilmaz OH , Katajisto P |
| Ref : Nature , 571 :398 , 2019 |
| Abstract : |
| PubMedSearch : Pentinmikko_2019_Nature_571_398 |
| PubMedID: 31292548 |
| Gene_locus related to this paper: human-NOTUM , mouse-notum |
| Title : Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling - Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| Author(s) : Suciu RM , Cognetta AB, 3rd , Potter ZE , Cravatt BF |
| Ref : ACS Med Chem Lett , 9 :563 , 2018 |
| Abstract : |
| PubMedSearch : Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| PubMedID: 29937983 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling - Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| Author(s) : Suciu RM , Cognetta AB, 3rd , Potter ZE , Cravatt BF |
| Ref : ACS Med Chem Lett , 9 :563 , 2018 |
| Abstract : |
| PubMedSearch : Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| PubMedID: 29937983 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling - Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| Author(s) : Suciu RM , Cognetta AB, 3rd , Potter ZE , Cravatt BF |
| Ref : ACS Med Chem Lett , 9 :563 , 2018 |
| Abstract : |
| PubMedSearch : Suciu_2018_ACS.Med.Chem.Lett_9_563 |
| PubMedID: 29937983 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Chemical Proteomic Profiling of Human Methyltransferases - Horning_2016_J.Am.Chem.Soc_138_13335 |
| Author(s) : Horning BD , Suciu RM , Ghadiri DA , Ulanovskaya OA , Matthews ML , Lum KM , Backus KM , Brown SJ , Rosen H , Cravatt BF |
| Ref : Journal of the American Chemical Society , 138 :13335 , 2016 |
| Abstract : |
| PubMedSearch : Horning_2016_J.Am.Chem.Soc_138_13335 |
| PubMedID: 27689866 |
| Title : Chemical Proteomic Profiling of Human Methyltransferases - Horning_2016_J.Am.Chem.Soc_138_13335 |
| Author(s) : Horning BD , Suciu RM , Ghadiri DA , Ulanovskaya OA , Matthews ML , Lum KM , Backus KM , Brown SJ , Rosen H , Cravatt BF |
| Ref : Journal of the American Chemical Society , 138 :13335 , 2016 |
| Abstract : |
| PubMedSearch : Horning_2016_J.Am.Chem.Soc_138_13335 |
| PubMedID: 27689866 |
| Title : Chemical Proteomic Profiling of Human Methyltransferases - Horning_2016_J.Am.Chem.Soc_138_13335 |
| Author(s) : Horning BD , Suciu RM , Ghadiri DA , Ulanovskaya OA , Matthews ML , Lum KM , Backus KM , Brown SJ , Rosen H , Cravatt BF |
| Ref : Journal of the American Chemical Society , 138 :13335 , 2016 |
| Abstract : |
| PubMedSearch : Horning_2016_J.Am.Chem.Soc_138_13335 |
| PubMedID: 27689866 |