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ABHD17-depalmitoylase

Relationship

Family: ABHD17-depalmitoylase

Block: X

Parent Family: Hydrolase_4

Comment

ABHD17 proteins are protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization (Lin and Conibear 2015) They are probably themselves palmitoylated. ABHD17A, 17B, and 17C, are identified as the physiological PSD-95 (the most abundant postsynaptic density scaffolding protein) depalmitoylating enzymes in neurones (Yokoi et al.). The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. They belong to a closely related family: LYsophospholipase_carboxylesterase

Database

Interpro : IPR022742 Hydrolase_4 Serine aminopeptidase, S33

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12146 Hydrolase_4

Prints : No Print

EC Number : 3.1.2.22

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Gene_locus Name Species
horvv-f2d0q6 Hordeum vulgare subsp. vulgare (Domesticated barley) Alpha\/Beta Hydrolase Domain-containing Protein 17 ert-k.32 dwarfing gene Hordeum vulgare subsp. vulgare
toxgo-TgASH3 Toxoplasma gondii (strain ATCC 50611 \/ Me49) TgASH3 Alpha\/beta hydrolase domain-containing protein 17A Toxoplasma gondii ME49
toxgo-a0a125yz56 Toxoplasma gondii ASH4 TgME49_262290 hydrolase TgASH4 Toxoplasma gondii
haeco-CDJ88804 Haemonchus contortus (barber pole worm) Abhydrolase domain-containing protein HcABHD Haemonchus contortus
anasp-ALL8511 Anabaena sp. (strain PCC 7120) hypothetical protein all8511 Anabaena sp.
anoga-q7qds9 Anopheles gambiae str. PEST ensangp00000010159 (fragment) Anopheles gambiae
arath-AT1G66900 Arabidopsis thaliana (Mouse-ear cress) ABAPT7 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase Arabidopsis thaliana
arath-AT2G24320 Arabidopsis thaliana (Mouse-ear cress) ABAPT9 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase at2g24320 Arabidopsis thaliana
arath-AT4G31020 Arabidopsis thaliana (Mouse-ear cress) ABAPT8 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase AT4G31020 F6I18.70 Arabidopsis thaliana
arath-AT5G38220 Arabidopsis thaliana (Mouse-ear cress) ABAPT2 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase Arabidopsis thaliana
arath-F3C3.3 Arabidopsis thaliana (Mouse-ear cress) ABAPT10 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase AT1G32190\/F3C3.3 Arabidopsis thaliana
arath-AT1G13610 Arabidopsis thaliana (Mouse-ear cress) ABAPT6 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase f13b4.9 f21f23.4 AT1G13610 Arabidopsis thaliana
arath-At5g14390 Arabidopsis thaliana (Mouse-ear cress) ABAPT3 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase At5g14390 Arabidopsis thaliana
arath-F22K18.40 Arabidopsis thaliana (Mouse-ear cress) ABAPT1 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase. F22K18.40 At4g24760 Arabidopsis thaliana
arath-At3g01690 Arabidopsis thaliana (Mouse-ear cress) ABAPT4 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase f28j7.1 at3g01690 Arabidopsis thaliana
arath-Q9LI62 Arabidopsis thaliana (Mouse-ear cress) ABAPT5 (Alpha\/Beta Hydrolase Domain-containing Protein 17)-like Acyl Protein Thioesterase At3g30380 Arabidopsis thaliana
bovin-AB17A Bos taurus (Bovine) Abhydrolase domain-containing protein FAM108A Bos taurus
bovin-AB17C Bos taurus (Bovine) Abhydrolase domain-containing protein FAM108C1 Bos taurus
caebr-A8Y1T9 Caenorhabditis briggsae hypothetical protein cbg22222 (fragment) Caenorhabditis briggsae
caebr-A8XYQ5 Caenorhabditis briggsae hypothetical protein cbg20828 (fragment) Caenorhabditis briggsae
caeel-F01D5.7 Caenorhabditis elegans f01d5.7 protein Caenorhabditis elegans
caeel-F01D5.8 Caenorhabditis elegans f01d5.8 protein Caenorhabditis elegans
caeel-K04G2.2 Caenorhabditis elegans k04g2.2 protein Caenorhabditis elegans
caeel-q5fc17 Caenorhabditis elegans. hypothetical protein Caenorhabditis elegans
caeel-Y71G12A.4 Caenorhabditis elegans hypothetical protein Caenorhabditis elegans
chick-q5zj01 Gallus gallus (Chicken) hypothetical protein AB17B Gallus gallus
crypv-q5cq99 Cryptosporidium parvum conserved protein, transcripts identified by est Cryptosporidium parvum
danre-Q7ZVZ7 Danio rerio (Zebrafish) (Brachydanio rerio) similar to riken cdna 2210412d01 gene Danio rerio
dicdi-q54f01 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
drome-CG11935 Drosophila melanogaster (Fruit fly) cg11935 protein or CG33096 Drosophila melanogaster
human-ABHD17A Homo sapiens (Human) Abhydrolase domain-containing protein FAM108A1, C19orf27 ABHD17A Homo sapiens
human-ABHD17B Homo sapiens (Human) CGI-67 C9orf77 FAM108B1 protein Abhydrolase domain-containing protein FAM108B1 Homo sapiens
human-ABHD17C Homo sapiens (Human) Abhydrolase domain-containing protein FAM108C1 Q6PCB6 F108C_HUMAN Homo sapiens
leima-q4q4j7 Leishmania major Putative serine peptidase Leishmania major
medtr-q2hux9 Medicago truncatula (Barrel medic) esterase\/lipase\/thioesterase Medicago truncatula
mimiv-q5uqk4 Acanthamoeba polyphaga mimivirus (APMV) putative alpha\/beta hydrolase l404 (EC 3.-.-.-) Mimivirus
mouse-q7m759 Mus musculus (Mouse) cgi67 serine protease precursor Mus musculus
mouse-Q8VCV1 Mus musculus (Mouse) hypothetical protein Mus musculus
mouse-Q99JW1 Mus musculus (Mouse) similar to cgi-67 protein AB17A Mus musculus
orysa-Q5N7J6 Oryza sativa (japonica cultivar-group\; f. spontanea, Red rice, Asian wild rice))\; Oryza glaberrima (African rice)\; Leersia perrieri p0519d04.53 os01g0689800 protein Oryza sativa
orysa-Q84SE0 Oryza sativa (japonica cultivar-group) p0577b11.1 protein Oryza sativa
orysa-q2qtq5 Oryza sativa (japonica cultivar-group) expressed protein Oryza sativa
orysa-q6kak2 Oryza sativa (japonica cultivar-group) hypothetical protein oj1004_e04.17 Oryza sativa
orysa-q6yuu0 Oryza sativa (japonica cultivar-group) putative cgi67 serine protease Oryza sativa
orysa-q67vk9 Oryza sativa (japonica cultivar-group) cgi67 serine protease-like Oryza sativa
ostta-q01e72 Ostreococcus tauri predicted alpha\/beta hydrolase (iss) Ostreococcus tauri
parte-a0dwm9 Paramecium tetraurelia chromosome undetermined scaffold_67, whole genome shotgun sequence Paramecium tetraurelia
plafa-MAL8P1.138 Plasmodium falciparum (isolate 3D7) PF3D7_0805000 hypothetical protein, conserved Plasmodium falciparum
plafa-PF11.0211 Plasmodium falciparum (isolate 3D7) PF3D7_1120400 hypothetical protein, conserved abh112 Plasmodium falciparum
plafa-PFD0185C Plasmodium falciparum (isolate 3D7) PF3D7_0403800 hypothetical protein, conserved RhoSH Plasmodium falciparum
ratno-q5xij5 Rattus norvegicus (Rat) similar to cdna sequence bc005632 AB17A Rattus norvegicus
ratno-q6ay17 Rattus norvegicus (Rat) AB17B hypothetical protein Rattus norvegicus
synja-q2jr17 Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone A-Prime) phospholipase\/carboxylesterase Synechococcus sp.
synjb-q2jq08 Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) phospholipase\/carboxylesterase family protein Synechococcus sp.
tetng-q4sd49 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetts-q22d15 Tetrahymena thermophila SB210 hypothetical protein Tetrahymena thermophila SB210
tetts-q22wp5 Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein Tetrahymena thermophila SB210
thean-q4uc78 Theileria annulata hypothetical protein Theileria annulata
trybr-Q4GYA0 Trypanosoma brucei conserved hypothetical protein Trypanosoma brucei
trycr-q4dbn1 Trypanosoma cruzi serine peptidase, putative Trypanosoma cruzi
trycr-q4dzp6 Trypanosoma cruzi serine peptidase, putative Trypanosoma cruzi
xenla-q3kq37 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xenla-q6dcc5 Xenopus laevis (African clawed frog) mgc83647 protein AB17B Xenopus laevis
xenla-q6dd70 Xenopus laevis (African clawed frog) mgc79044 protein AB17C Xenopus laevis
xentr-q5m904 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) hypothetical loc496639 Xenopus tropicalis
xentr-q6dey3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) mgc89389 protein Xenopus tropicalis
xentr-q6gl10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) mgc69445 protein Xenopus tropicalis
9alve-a0a0g4hsy5 Chromera velia Uncharacterized protein Chromera velia
rat-ab17c Rattus norvegicus (Rat). Alpha\/beta hydrolase domain-containing protein 17C Rattus norvegicus
wheat-a0a3b6np36 Triticum aestivum (Wheat). Alpha\/beta hydrolase 17 domain-containing protein Triticum aestivum
panvg-a0a8t0x4g0 Panicum virgatum (Blackwell switchgrass). Alpha\/beta hydrolase 17 domain-containing protein Panicum virgatum
setit-k3ysv0 Setaria italica (Foxtail millet) (Panicum italicum). Alpha\/beta hydrolase 17 domain-containing protein Setaria italica
sorbi-c5xx30 Sorghum bicolor (Sorghum) (Sorghum vulgare). Alpha\/beta hydrolase 17 domain-containing protein Sorghum bicolor
horvv-f2dfe3 Hordeum vulgare subsp. vulgare (Domesticated barley). Predicted protein Hordeum vulgare subsp. vulgare
bradi-i1gx49 Brachypodium distachyon (Purple false brome) (Trachynia distachya). Alpha\/beta hydrolase 17 domain-containing protein Brachypodium distachyon
maize-c4j9a1 Zea mays (Maize). Alpha\/beta hydrolase 17 domain-containing protein Zea mays
bradi-i1i839 Brachypodium distachyon (Purple false brome) (Trachynia distachya). Alpha\/beta hydrolase 17 domain-containing protein Brachypodium distachyon
horvv-f2db09 Hordeum vulgare subsp. vulgare (Domesticated barley). Predicted protein Hordeum vulgare subsp. vulgare
panvg-a0a8t0rhr6 Panicum virgatum (Blackwell switchgrass). Alpha\/beta hydrolase 17 domain-containing protein Panicum virgatum
papso-a0a4y7jba3 Papaver somniferum (Opium poppy). Alpha\/beta hydrolase 17 domain-containing protein Papaver somniferum
zinof-a0a8j5gty0 Zingiber officinale (Ginger) (Amomum zingiber). Alpha\/beta hydrolase 17 domain-containing protein Zingiber officinale
cajca-a0a151r0b7 Cajanus cajan (Pigeon pea) (Cajanus indicus). Abhydrolase domain-containing protein FAM108C1 family Cajanus cajan
setit-k3xj49 Setaria italica (Foxtail millet) (Panicum italicum). Alpha\/beta hydrolase 17 domain-containing protein Setaria italica
aspof-a0a5p1ew48 Asparagus officinalis (Garden asparagus). Alpha\/beta hydrolase 17 domain-containing protein Asparagus officinalis
cocnu-a0a8k0hu18 Cocos nucifera (Coconut palm). Alpha\/beta hydrolase domain-containing protein 17C Cocos nucifera

Gene_locus_frgt Name Species
tetts-q24fe9 Tetrahymena thermophila SB210 hypothetical protein Tetrahymena thermophila SB210
panmi-a0a3l6pme8 Panicum miliaceum (Proso millet) (Broomcorn millet). Alpha\/beta hydrolase domain-containing protein 17B isoform X2 Panicum miliaceum

Substrate Chemical Nomenclature Proteins
Depalmitoylation-probe-2 S-[(2R)-2-[[6'-(dimethylamino)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxycarbonyl-methylamino]-3-(methylamino)-3-oxopropyl] octanethioate human-LYPLA1    human-LYPLA2    human-ABHD17A    human-ABHD10    mouse-abhda

Inhibitor Chemical Nomenclature Proteins
ABD957 2-[8-[2-[[(3S)-4-[3-(dimethylsulfamoyl)pyrazole-1-carbonyl]-3-methylpiperazin-1-yl]methyl]-5-(trifluoromethyl)phenyl]-3,8-diazabicyclo[3.2.1]octan-3-yl]acetic acid human-ABHD17B
CID155803786 N,N-dimethyl-1-[(2S)-2-methyl-4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-3-sulfonamide human-ABHD17B
CID155803792 N,N-dimethyl-1-[4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-3-sulfonamide human-ABHD17B    human-LYPLA1
CID155803782 N,N-dimethyl-1-[4-[[2-morpholin-4-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carbonyl]pyrazole-4-sulfonamide human-ABHD17B    human-LYPLA1
CID155803778 1-[4-[(4-chlorophenyl)methyl]piperazine-1-carbonyl]-N,N-dimethylpyrazole-4-sulfonamide human-ABHD17B    human-LYPLA1
HDFP 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane human-PREPL
Palmostatin-M (3S,4S)-3-decyl-4-[4-[3-(dimethylamino)propylsulfonyl]butyl]oxetan-2-one human-LYPLA1    human-LYPLA2    human-PREPL
Palmostatin-B (3S,4S)-3-decyl-4-[2-(3,4-dimethoxyphenyl)ethyl]oxetan-2-one human-ABHD16A    human-ABHD6    human-FASN    human-ABHD17A    human-ABHD17B    human-ABHD17C    human-LYPLA1    human-LYPLA2    human-PREPL
Sal-A-alkyne plafa-PF10.0020    plafa-PF07.0040    plafa-a0a143zya4    plafa-PF10.0379    plafa-PF13.0153    plaf7-q8iik5    plaf7-q8ii19    plafa-MAL8P1.138
Salinipostin-A (3R,8aS)-5-butyl-3-oxo-3-pentadecoxy-8,8a-dihydro-1H-furo[3,4-e][1,3,2]dioxaphosphepin-6-one plafa-PF10.0020    plafa-PF07.0040    plafa-a0a143zya4    plafa-PF10.0379    plafa-PF13.0153    plaf7-q8iik5    plaf7-q8ii19    plafa-MAL8P1.138

References (12)

Title : Deacylases-structure, function, and relationship to diseases - Wang_2024_FEBS.Lett_598_959
Author(s) : Wang S , Xing X , Ma J , Zheng S , Song Q , Zhang P
Ref : FEBS Letters , 598 :959 , 2024
Abstract :
PubMedSearch : Wang_2024_FEBS.Lett_598_959
PubMedID: 38644468

Title : Attenuating ABHD17 enhances S- palmitoylation, membrane localization and signal transduction of NOD2 and Crohn's disease-associated variants - Dixon_2023_bioRxiv__
Author(s) : Dixon CL , Martin NR , Niphakis MJ , Cravatt BF , Fairn GD
Ref : Biorxiv , : , 2023
Abstract :
PubMedSearch : Dixon_2023_bioRxiv__
PubMedID: 38187608

Title : Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation - Suciu_2021_Bioorg.Med.Chem.Lett_53_128414
Author(s) : Suciu RM , Luvaga IK , Hazeen A , Weerasooriya C , Richardson SK , Firestone AJ , Shannon K , Howell AR , Cravatt BF
Ref : Bioorganic & Medicinal Chemistry Lett , 53 :128414 , 2021
Abstract :
PubMedSearch : Suciu_2021_Bioorg.Med.Chem.Lett_53_128414
PubMedID: 34666187

Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__
Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF
Ref : Nat Chemical Biology , : , 2021
Abstract :
PubMedSearch : Remsberg_2021_Nat.Chem.Biol__
PubMedID: 33927411
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Site specific deacylation by ABHD17a controls BK channel splice variant activity - McClafferty_2020_J.Biol.Chem_295_16487
Author(s) : McClafferty H , Runciman H , Shipston MJ
Ref : Journal of Biological Chemistry , 295 :16487 , 2020
Abstract :
PubMedSearch : McClafferty_2020_J.Biol.Chem_295_16487
PubMedID: 32913120
Gene_locus related to this paper: human-ABHD17A

Title : Systematic Screening of Depalmitoylating Enzymes and Evaluation of Their Activities by the Acyl-PEGyl Exchange Gel-Shift (APEGS) Assay - Kanadome_2019_Methods.Mol.Biol_2009_83
Author(s) : Kanadome T , Yokoi N , Fukata Y , Fukata M
Ref : Methods Mol Biol , 2009 :83 , 2019
Abstract :
PubMedSearch : Kanadome_2019_Methods.Mol.Biol_2009_83
PubMedID: 31152397

Title : Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle - Won_2018_ACS.Chem.Biol_13_1560
Author(s) : Won SJ , Martin BR
Ref : ACS Chemical Biology , 13 :1560 , 2018
Abstract :
PubMedSearch : Won_2018_ACS.Chem.Biol_13_1560
PubMedID: 29733200

Title : Protein depalmitoylases - Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83
Author(s) : Won SJ , Cheung See Kit M , Martin BR
Ref : Crit Rev Biochem Mol Biol , 53 :83 , 2018
Abstract :
PubMedSearch : Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83
PubMedID: 29239216

Title : Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization - Tortosa_2017_Neuron_94_809
Author(s) : Tortosa E , Adolfs Y , Fukata M , Pasterkamp RJ , Kapitein LC , Hoogenraad CC
Ref : Neuron , 94 :809 , 2017
Abstract :
PubMedSearch : Tortosa_2017_Neuron_94_809
PubMedID: 28521134
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Identification of PSD-95 Depalmitoylating Enzymes - Yokoi_2016_J.Neurosci_36_6431
Author(s) : Yokoi N , Fukata Y , Sekiya A , Murakami T , Kobayashi K , Fukata M
Ref : Journal of Neuroscience , 36 :6431 , 2016
Abstract :
PubMedSearch : Yokoi_2016_J.Neurosci_36_6431
PubMedID: 27307232
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C , rat-ab17c

Title : ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization - Lin_2015_Elife_4_
Author(s) : Lin DT , Conibear E
Ref : Elife , 4 : , 2015
Abstract :
PubMedSearch : Lin_2015_Elife_4_
PubMedID: 26701913
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Large-scale profiling of protein palmitoylation in mammalian cells - Martin_2009_Nat.Methods_6_135
Author(s) : Martin BR , Cravatt BF
Ref : Nat Methods , 6 :135 , 2009
Abstract :
PubMedSearch : Martin_2009_Nat.Methods_6_135
PubMedID: 19137006
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C