ABHD17-depalmitoylase

Relationship

Family: ABHD17-depalmitoylase

Block: X

Parent Family: Hydrolase_4

Comment

ABHD17 proteins are protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization (Lin and Conibear 2015) They are probably themselves palmitoylated. ABHD17A, 17B, and 17C, are identified as the physiological PSD-95 (the most abundant postsynaptic density scaffolding protein) depalmitoylating enzymes in neurones (Yokoi et al.). The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. They belong to a closely related family: LYsophospholipase_carboxylesterase

Database

Interpro : IPR022742 Hydrolase_4 Serine aminopeptidase, S33

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12146 Hydrolase_4

Prints : No Print

EC Number : 3.1.2.22

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in ABHD17-depalmitoylase family (85)

Fragments of genes in ABHD17-depalmitoylase family (2)

No fragment of genes

Substrates in ABHD17-depalmitoylase family (1)

Inhibitors in ABHD17-depalmitoylase family (10)

References (11)

Title : Attenuating ABHD17 enhances S- palmitoylation, membrane localization and signal transduction of NOD2 and Crohn's disease-associated variants - Dixon_2023_bioRxiv__
Author(s) : Dixon CL , Martin NR , Niphakis MJ , Cravatt BF , Fairn GD
Ref : Biorxiv , : , 2023
PubMedID: 38187608

Title : Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation - Suciu_2021_Bioorg.Med.Chem.Lett_53_128414
Author(s) : Suciu RM , Luvaga IK , Hazeen A , Weerasooriya C , Richardson SK , Firestone AJ , Shannon K , Howell AR , Cravatt BF
Ref : Bioorganic & Medicinal Chemistry Lett , 53 :128414 , 2021
PubMedID: 34666187

Title : ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth - Remsberg_2021_Nat.Chem.Biol__
Author(s) : Remsberg JR , Suciu RM , Zambetti NA , Hanigan TW , Firestone AJ , Inguva A , Long A , Ngo N , Lum KM , Henry CL , Richardson SK , Predovic M , Huang B , Dix MM , Howell AR , Niphakis MJ , Shannon K , Cravatt BF
Ref : Nat Chemical Biology , : , 2021
PubMedID: 33927411
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Site specific deacylation by ABHD17a controls BK channel splice variant activity - McClafferty_2020_J.Biol.Chem_295_16487
Author(s) : McClafferty H , Runciman H , Shipston MJ
Ref : Journal of Biological Chemistry , 295 :16487 , 2020
PubMedID: 32913120
Gene_locus related to this paper: human-ABHD17A

Title : Systematic Screening of Depalmitoylating Enzymes and Evaluation of Their Activities by the Acyl-PEGyl Exchange Gel-Shift (APEGS) Assay - Kanadome_2019_Methods.Mol.Biol_2009_83
Author(s) : Kanadome T , Yokoi N , Fukata Y , Fukata M
Ref : Methods Mol Biol , 2009 :83 , 2019
PubMedID: 31152397

Title : Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle - Won_2018_ACS.Chem.Biol_13_1560
Author(s) : Won SJ , Martin BR
Ref : ACS Chemical Biology , 13 :1560 , 2018
PubMedID: 29733200

Title : Protein depalmitoylases - Won_2018_Crit.Rev.Biochem.Mol.Biol_53_83
Author(s) : Won SJ , Cheung See Kit M , Martin BR
Ref : Crit Rev Biochem Mol Biol , 53 :83 , 2018
PubMedID: 29239216

Title : Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization - Tortosa_2017_Neuron_94_809
Author(s) : Tortosa E , Adolfs Y , Fukata M , Pasterkamp RJ , Kapitein LC , Hoogenraad CC
Ref : Neuron , 94 :809 , 2017
PubMedID: 28521134
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Identification of PSD-95 Depalmitoylating Enzymes - Yokoi_2016_J.Neurosci_36_6431
Author(s) : Yokoi N , Fukata Y , Sekiya A , Murakami T , Kobayashi K , Fukata M
Ref : Journal of Neuroscience , 36 :6431 , 2016
PubMedID: 27307232
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C , rat-ab17c

Title : ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization - Lin_2015_Elife_4_
Author(s) : Lin DT , Conibear E
Ref : Elife , 4 : , 2015
PubMedID: 26701913
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C

Title : Large-scale profiling of protein palmitoylation in mammalian cells - Martin_2009_Nat.Methods_6_135
Author(s) : Martin BR , Cravatt BF
Ref : Nat Methods , 6 :135 , 2009
PubMedID: 19137006
Gene_locus related to this paper: human-ABHD17A , human-ABHD17B , human-ABHD17C