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Family Report for: ABHD17-depalmitoylase


ABHD17-depalmitoylase



Relationship
Block X
Parent Family : Hydrolase_4


Comments

ABHD17 proteins are protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization (Lin and Conibear 2015) They are probably themselves palmitoylated. ABHD17A, 17B, and 17C, are identified as the physiological PSD-95 (the most abundant postsynaptic density scaffolding protein) depalmitoylating enzymes in neurones (Yokoi et al.). The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. They belong to a closely related family: LYsophospholipase_carboxylesterase



Database
Sequences
Interpro : IPR022742 (Hydrolase_4 Serine aminopeptidase, S33)
PIRSF :
Pdoc :
PFam : PF12146 (Hydrolase_4)
Prints :
Prosite :
EC at KEGG : 3.1.2.22
EC at EXPASY : 3.1.2.22
Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin : Text only/graphic display
Seed alignment with MAFFT : No colour/coloured with Mview
Alignment with MAFFT : No colour/coloured with Mview
Dendrogram : Graphical display, obtained with the dnd file produced by Clustalw
HMM profile : HMM profile


No Image

No Structure

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Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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