Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Epoxide-hydrolase_like

Epoxide-hydrolase_like



Relationship
Block X


Comment
This family closely related to Abhydrolase_6 contains previously separated families (in Pfam they are partially included in Abhydrolase_6). In epoxide hydrolase, haloalkane dehalogenase, haloacetate_dehalogenase, the catalytic triad nucleophile is an invariable aspartate. Asp attacks a carbon of the epoxide moiety, opening the ring and forming an ester-linked substrate-enzyme intermediate complex. An activated water molecule, hydrolyzes the ester bond and releases diol as the product of catalysis. Two Tyr residues are located on the opposite side of the active site from the nucleophile. They hydrogen bond with the epoxide oxygen, positioning the substrate in the active site for nucleophilic attack. In Cif one of the Tyr is replaced by His
2 Disease(s)

1 Risk(s) factors

1 Xenobiotic(s) sensitivity


Database
Sequences
Interpro
|
IPR000639 (Epoxide hydrolase-like), IPR016292 (Epoxide hydrolase), IPR010497 (Epoxide hydrolase, N-terminal)
PIRSF
|
Pdoc
|
PFam
|
PF12697 (Abhydrolase_6)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: alpha/beta-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase
    Pusch LM, Riegler-Berket L, Oberer M, Zimmermann R, Taschler U
    Ref: Metabolites, 12:, 2022 : PubMed

            

    Title: Epoxide hydrolases: structure, function, mechanism, and assay
    Arand M, Cronin A, Adamska M, Oesch F
    Ref: Methods Enzymol, 400:569, 2005 : PubMed

            

    Title: The telltale structures of epoxide hydrolases
    Arand M, Cronin A, Oesch F, Mowbray SL, Jones TA
    Ref: Drug Metabolism Reviews, 35:365, 2003 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Epoxide-hydrolase_like family (440)

Genes Proteins in Epoxide-hydrolase_like family (2361)

Fragments of genes in Epoxide-hydrolase_like family (129)

Substrates of some enzymes in the Epoxide-hydrolase_like family (1)

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer