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Family Report for: Epoxide-hydrolase_like


Block X

This family closely related to Abhydrolase_6 contains previously separated families (in Pfam they are partially included in Abhydrolase_6). In epoxide hydrolase, haloalkane dehalogenase, haloacetate_dehalogenase, the catalytic triad nucleophile is an invariable aspartate. Asp attacks a carbon of the epoxide moiety, opening the ring and forming an ester-linked substrate-enzyme intermediate complex. An activated water molecule, hydrolyzes the ester bond and releases diol as the product of catalysis. Two Tyr residues are located on the opposite side of the active site from the nucleophile. They hydrogen bond with the epoxide oxygen, positioning the substrate in the active site for nucleophilic attack. In Cif one of the Tyr is replaced by His
2 Disease(s)

1 Risk(s) factors

1 Xenobiotic(s) sensitivity

IPR000639 (Epoxide hydrolase-like), IPR016292 (Epoxide hydrolase), IPR010497 (Epoxide hydrolase, N-terminal)
PF12697 (Abhydrolase_6)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

    Title: alpha/beta-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase
    Pusch LM, Riegler-Berket L, Oberer M, Zimmermann R, Taschler U
    Ref: Metabolites, 12:, 2022 : PubMed


    Title: Epoxide hydrolases: structure, function, mechanism, and assay
    Arand M, Cronin A, Adamska M, Oesch F
    Ref: Methods Enzymol, 400:569, 2005 : PubMed


    Title: The telltale structures of epoxide hydrolases
    Arand M, Cronin A, Oesch F, Mowbray SL, Jones TA
    Ref: Drug Metabolism Reviews, 35:365, 2003 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Epoxide-hydrolase_like family (477)

Genes Proteins in Epoxide-hydrolase_like family (2379)

Fragments of genes in Epoxide-hydrolase_like family (129)

Substrates of some enzymes in the Epoxide-hydrolase_like family (1)

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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