9gamm-BioJ
Francisella philomiragia BioJ pimeloyl-ACP methyl ester esterase
Comment
The FTN_0818 gene required for Francisella virulence is involved in biotin metabolism. This protein named BioJ is the enzyme of the biotin biosynthesis pathway that determines the chain length of the biotin valeryl side-chain. It is the functionnal equivalent of BioH although it shows low homology to BioH. Other strains: Francisella philomiragia subsp. philomiragia ATCC 25015\; Francisella noatunensis\; Francisella sp. TX077308
Relationship
Family : Hormone-sensitive_lipase_like
Block : H
Position in NCBI Life Tree : Francisella philomiragia subsp. philomiragia ATCC 25015
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Thiotrichales N E > Francisellaceae N E > Francisella N E > Francisella philomiragia N E > Francisella philomiragia subsp. philomiragia ATCC 25015 N EMolecular evidence
Sequence
Peptide
MPYHPALESL LDTPEIRKIK KLDLRDQRKI FADLSIAQIK RLPRPDIIEE DIKLENDTIL RHYKPKKASD KAVLFIHGGG WCLSSIDTYD HVCRYLCDQG NLNIFSLEYG LGPEDKYPAA VNHALYAYDW LYENITKFNL STENIFVMGD SAGGNLVTII CHERQENMPK AQILVYPAVD MYTKYDSNTK FDEYKYHLTT EWCELFLKAY IGEDIMSEPK KLRQPTISPL FYKDTKQPDT LIVAATHDIL IDGIYAYEEK LKQQGTYVET HYDDEMYHGF IGGLGVVPFE NPKIALDKII EFINKR
References (4)
| Title : Molecular Basis of BioJ, a Unique Gatekeeper in Bacterial Biotin Synthesis - Wei_2019_iScience_19_796 |
| Author(s) : Wei W , Guan H , Zhu T , Zhang S , Fan C , Ouyang S , Feng Y |
| Ref : iScience , 19 :796 , 2019 |
| Abstract : |
| PubMedSearch : Wei_2019_iScience_19_796 |
| PubMedID: 31494495 |
| Gene_locus related to this paper: 9gamm-BioJ |
| Title : A Biotin Biosynthesis Gene Restricted to Helicobacter - Bi_2016_Sci.Rep_6_21162 |
| Author(s) : Bi H , Zhu L , Jia J , Cronan JE |
| Ref : Sci Rep , 6 :21162 , 2016 |
| Abstract : |
| PubMedSearch : Bi_2016_Sci.Rep_6_21162 |
| PubMedID: 26868423 |
| Gene_locus related to this paper: 9gamm-BioJ , helpy-o25061 |
| Title : A Francisella virulence factor catalyses an essential reaction of biotin synthesis - Feng_2014_Mol.Microbiol_91_300 |
| Author(s) : Feng Y , Napier BA , Manandhar M , Henke SK , Weiss DS , Cronan JE |
| Ref : Molecular Microbiology , 91 :300 , 2014 |
| Abstract : |
| PubMedSearch : Feng_2014_Mol.Microbiol_91_300 |
| PubMedID: 24313380 |
| Gene_locus related to this paper: 9gamm-BioJ , fratt-q5nga8 |
| Title : Biotin synthesis begins by hijacking the fatty acid synthetic pathway. - Lin_2010_Nat.Chem.Biol_6_682 |
| Author(s) : Lin S , Hanson RE , Cronan JE |
| Ref : Nat Chemical Biology , 6 :682 , 2010 |
| Abstract : |
| PubMedSearch : Lin_2010_Nat.Chem.Biol_6_682 |
| PubMedID: 20693992 |
| Gene_locus related to this paper: 9gamm-BioJ , ecoli-bioh |