Francisella tularensis (subsp. tularensis, holarctica, novicida, mediasiatica), Francisella novicida, pimeloyl-ACP methyl ester esterase BioJ
The FTN_0818 gene required for Francisella virulence is involved in biotin metabolism. This protein named BioJ is the enzyme of the biotin biosynthesis pathway that determines the chain length of the biotin valeryl side-chain. It is the functionnal equivalent of BioH although it shows low homology to BioH. Other strains: Francisella tularensis (subsp. tularensis (SCHU S4 \/ Schu 4\; MA00-2987\; WY96-3418\; NE061598\; FSC033\; FSC 198), holarctica (LVS\; FSC022\; FTNF002-00 \/ FTA\; 257\; OSU18), novicida (U112), mediasiatica (FSC147)), Francisella novicida (FTG\; GA99-3548\; FTE\; GA99-3549)
Family : Hormone-sensitive_lipase_like
Block : H
Position in NCBI Life Tree : Francisella tularensis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Thiotrichales N E > Francisellaceae N E > Francisella N E > Francisella tularensis N EMPYNPSLEAL LDTPEIRRIK KLDLTQQREI FTSLSVEQLK RLPRPDILEE DIKLENNTIL RHYQPKKSSN KAVLFIHGGG WCLGSINTYD HVCRYLCDQG NLNIFSLEYG LAPEQKYPAA VDHALYAYDW LYQNINKFKI SAENIFVMGD SAGGNLVTIV CHERQENMPK AQILVYPAVD MYTKYDSNKK FDENKYHLTT EWCELFLKAY IGEDVMSEPK KLRHPTISPL FYKDTKQPDT LIVAATHDIL IDGIYAYEEK LKQQGTYVET YYDDEMFHGF MGILGITPFE NPKIALNKVI EFINKR
| Title : Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context - Cao_2017_Sci.Rep_7_2141 |
| Author(s) : Cao X , Zhu L , Hu Z , Cronan JE |
| Ref : Sci Rep , 7 :2141 , 2017 |
| Abstract : |
| PubMedSearch : Cao_2017_Sci.Rep_7_2141 |
| PubMedID: 28526858 |
| Gene_locus related to this paper: fratt-q5nga8 , pseae-PA0502 |
| Title : The unusual substrate specificity of a virulence associated serine hydrolase from the highly toxic bacterium, Francisella tularensis - Farberg_2016_Biochem.Biophys.Rep_7_415 |
| Author(s) : Farberg AM , Hart WK , Johnson RJ |
| Ref : Biochem Biophys Rep , 7 :415 , 2016 |
| Abstract : |
| PubMedSearch : Farberg_2016_Biochem.Biophys.Rep_7_415 |
| PubMedID: |
| Gene_locus related to this paper: fratt-q5nga8 |
| Title : A Francisella virulence factor catalyses an essential reaction of biotin synthesis - Feng_2014_Mol.Microbiol_91_300 |
| Author(s) : Feng Y , Napier BA , Manandhar M , Henke SK , Weiss DS , Cronan JE |
| Ref : Molecular Microbiology , 91 :300 , 2014 |
| Abstract : |
| PubMedSearch : Feng_2014_Mol.Microbiol_91_300 |
| PubMedID: 24313380 |
| Gene_locus related to this paper: 9gamm-BioJ , fratt-q5nga8 |
| Title : Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence - Petrosino_2006_J.Bacteriol_188_6977 |
| Author(s) : Petrosino JF , Xiang Q , Karpathy SE , Jiang H , Yerrapragada S , Liu Y , Gioia J , Hemphill L , Gonzalez A , Raghavan TM , Uzman A , Fox GE , Highlander S , Reichard M , Morton RJ , Clinkenbeard KD , Weinstock GM |
| Ref : Journal of Bacteriology , 188 :6977 , 2006 |
| Abstract : |
| PubMedSearch : Petrosino_2006_J.Bacteriol_188_6977 |
| PubMedID: 16980500 |
| Gene_locus related to this paper: fratt-q5ng35 , fratt-q5nga8 , fratt-q5ngu5 , fratu-q7wvf7 |
| Title : The complete genome sequence of Francisella tularensis, the causative agent of tularemia - Larsson_2005_Nat.Genet_37_153 |
| Author(s) : Larsson P , Oyston PC , Chain P , Chu MC , Duffield M , Fuxelius HH , Garcia E , Halltorp G , Johansson D , Isherwood KE , Karp PD , Larsson E , Liu Y , Michell S , Prior J , Prior R , Malfatti S , Sjostedt A , Svensson K , Thompson N , Vergez L , Wagg JK , Wren BW , Lindler LE , Andersson SG , Forsman M , Titball RW |
| Ref : Nat Genet , 37 :153 , 2005 |
| Abstract : |
| PubMedSearch : Larsson_2005_Nat.Genet_37_153 |
| PubMedID: 15640799 |
| Gene_locus related to this paper: fratt-q5ng35 , fratt-q5nga8 , fratt-q5ngu5 , fratt-q5ni32 , fratu-q7wvf7 |