aspor-PKSL1

Aspergillus oryzae and Aspergillus sp. L Aspergillus flavus Aspergillus parasiticus aflatoxin biosynthesis pksa polyketide synthase

Comment

Relationship

Family : Thioesterase

Block : X

Position in NCBI Life Tree : Aspergillus oryzae

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Aspergillaceae N E > Aspergillus N E > Aspergillus oryzae N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Sequence

Peptide

ANTQVSSQAI PAEATHSHTP PQPKHSPVPE TAGSAPAAKG VGVSNEKLDA VMRVVSEESG IALEELTDDS NFADMGIDSL SSMVIGSRFR EDLGLDLGPE FSLFIDCTTV RALKDFMLGS GDAGSGSNVE DPPPSATPGI NPEIDWSSSA SDSIFASEDH DHSSESGADT GSPPALDLKP YCRPSTSVVL QGLPMVARKT LFMLPDGGGS AFSYASLPRL KSDTAVVGLN CPYARDPENM NCTHGAMIES FCNEIRRRQP RGPYHLGGWS SGGAFAYVVA EALVNQGEEV HSLIIIDAPI PQAMEQLPRA FYEHCNSIGL FATQPGASPD GSTEPPSYLI LHFIAVVDVM LDYKLAPLHA RRMPKVGIVW AADTVMDERD APKMKGMHFM IQKRTEFGPD GWDTIMPGAS FDIVRADGAN HFTLMQKEHV SIISDLIDRV MA

References (10)

Title : Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis - Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246
Author(s) : Korman TP , Crawford JM , Labonte JW , Newman AG , Wong J , Townsend CA , Tsai SC
Ref : Proc Natl Acad Sci U S A , 107 :6246 , 2010
Abstract :
PubMedSearch : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246
PubMedID: 20332208
Gene_locus related to this paper: aspor-PKSL1

Title : Deconstruction of iterative multidomain polyketide synthase function - Crawford_2008_Science_320_243
Author(s) : Crawford JM , Thomas PM , Scheerer JR , Vagstad AL , Kelleher NL , Townsend CA
Ref : Science , 320 :243 , 2008
Abstract :
PubMedSearch : Crawford_2008_Science_320_243
PubMedID: 18403714
Gene_locus related to this paper: aspor-PKSL1 , asppa-q6ueg5

Title : Molecular analysis of an inactive aflatoxin biosynthesis gene cluster in Aspergillus oryzae RIB strains - Tominaga_2006_Appl.Environ.Microbiol_72_484
Author(s) : Tominaga M , Lee YH , Hayashi R , Suzuki Y , Yamada O , Sakamoto K , Gotoh K , Akita O
Ref : Applied Environmental Microbiology , 72 :484 , 2006
Abstract :
PubMedSearch : Tominaga_2006_Appl.Environ.Microbiol_72_484
PubMedID: 16391082
Gene_locus related to this paper: aspor-PKSL1 , asppa-q6ueg5

Title : Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation - Ehrlich_2004_Appl.Environ.Microbiol_70_6518
Author(s) : Ehrlich KC , Chang PK , Yu J , Cotty PJ
Ref : Applied Environmental Microbiology , 70 :6518 , 2004
Abstract :
PubMedSearch : Ehrlich_2004_Appl.Environ.Microbiol_70_6518
PubMedID: 15528514
Gene_locus related to this paper: aspfl-q5vdc0 , aspno-q5vd72 , aspno-q5vd79 , aspor-PKSL1 , aspor-q2ufz8

Title : Clustered pathway genes in aflatoxin biosynthesis -
Author(s) : Yu J , Chang PK , Ehrlich KC , Cary JW , Bhatnagar D , Cleveland TE , Payne GA , Linz JE , Woloshuk CP , Bennett JW
Ref : Applied Environmental Microbiology , 70 :1253 , 2004
PubMedID: 15006741
Gene_locus related to this paper: aspor-PKSL1 , asppa-q6ueg5

Title : Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus - Yu_2004_FEBS.Lett_564_126
Author(s) : Yu J , Bhatnagar D , Cleveland TE
Ref : FEBS Letters , 564 :126 , 2004
Abstract :
PubMedSearch : Yu_2004_FEBS.Lett_564_126
PubMedID: 15094053
Gene_locus related to this paper: aspor-PKSL1 , asppa-q6ueg5

Title : Variability in nitrogen regulation of aflatoxin production by Aspergillus flavus strains - Ehrlich_2002_Appl.Microbiol.Biotechnol_60_174
Author(s) : Ehrlich KC , Cotty PJ
Ref : Applied Microbiology & Biotechnology , 60 :174 , 2002
Abstract :
PubMedSearch : Ehrlich_2002_Appl.Microbiol.Biotechnol_60_174
PubMedID: 12382060
Gene_locus related to this paper: aspfl-q5vdc0 , aspor-PKSL1

Title : Promoter elements in the aflatoxin pathway polyketide synthase gene - Ehrlich_2002_Biochim.Biophys.Acta_1576_171
Author(s) : Ehrlich KC , Montalbano BG , Cary JW , Cotty PJ
Ref : Biochimica & Biophysica Acta , 1576 :171 , 2002
Abstract :
PubMedSearch : Ehrlich_2002_Biochim.Biophys.Acta_1576_171
PubMedID: 12031498
Gene_locus related to this paper: aspor-PKSL1

Title : Characterization of the polyketide synthase gene (pksL1) required for aflatoxin biosynthesis in Aspergillus parasiticus - Feng_1995_J.Bacteriol_177_6246
Author(s) : Feng GH , Leonard TJ
Ref : Journal of Bacteriology , 177 :6246 , 1995
Abstract :
PubMedSearch : Feng_1995_J.Bacteriol_177_6246
PubMedID: 7592391
Gene_locus related to this paper: aspor-PKSL1

Title : The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis - Chang_1995_Mol.Gen.Genet_248_270
Author(s) : Chang PK , Cary JW , Yu J , Bhatnagar D , Cleveland TE
Ref : Molecular & General Genetics , 248 :270 , 1995
Abstract :
PubMedSearch : Chang_1995_Mol.Gen.Genet_248_270
PubMedID: 7565588
Gene_locus related to this paper: aspor-PKSL1