aspte-AT1

Aspergillus terreus polyketide synthase. Terrein biosynthesis cluster protein terA, from aa 1680 thioesterase module

Comment

Other strains: Aspergillus terreus (strain NIH 2624 \/ FGSC A1156)

Relationship

Family : Thioesterase

Block : X

Position in NCBI Life Tree : Aspergillus terreus

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

IGLDSLMSLS ITGRMREELD LEAIPSSVFT DYPTVGQVKA LILKLVGTSS DETTTAPPED EEEDPATADA DNSEMIRENP LESMSPNVSS SEAMDGFLAI VCEEVGVDLE ELLEVQNFAG AGVDSLMSLT ITGRAREDLD MDIPSSFFVD YPTVDQARLA IASLMGGGDQ TGATTPYSGS DDAKSSTSSL TAGSVLTPDD DTEAQDISQL TRPATSIVLQ GSLKTASKTL FLLPDGSGSA TSYAALPRLS PDTCVVALNC PFMKTPSEYT TGIEGVAALY LSEIRRRQPE GPYVLGGWSA GGILAYAVDA VACQLIEMGE EIEDLFLIDS PCPINLQPLP SELLHFIDSL GLLGAQGSAP KWLIPHFEAS IKNLTAFVPH AMDPDEAPRT HIIWARDGLV SKSDEKQFPR SDAEAKSVRF LLDGRQNLGT YGWEKLIGSE NISVDFIEGN HFTMMREPKV SPPYLSLTHR KILTLQSR

References

Title : Terrein reduces age-related inflammation induced by oxidative stress through Nrf2\/ERK1\/2\/HO-1 signalling in aged HDF cells - Lee_2015_Cell.Biochem.Funct_33_479
Author(s) : Lee YH , Lee SJ , Jung JE , Kim JS , Lee NH , Yi HK
Ref : Cell Biochemistry & Function , 33 :479 , 2015
Abstract : Lee_2015_Cell.Biochem.Funct_33_479
ESTHER : Lee_2015_Cell.Biochem.Funct_33_479
PubMedSearch : Lee_2015_Cell.Biochem.Funct_33_479
PubMedID: 26416516
Gene_locus related to this paper: aspte-AT1

Title : Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals - Gressler_2015_Elife_4_e07861
Author(s) : Gressler M , Meyer F , Heine D , Hortschansky P , Hertweck C , Brock M
Ref : Elife , 4 : , 2015
Abstract : Gressler_2015_Elife_4_e07861
ESTHER : Gressler_2015_Elife_4_e07861
PubMedSearch : Gressler_2015_Elife_4_e07861
PubMedID: 26173180
Gene_locus related to this paper: aspte-AT1

Title : A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster - Gressler_2015_Front.Microbiol_6_184
Author(s) : Gressler M , Hortschansky P , Geib E , Brock M
Ref : Front Microbiol , 6 :184 , 2015
Abstract : Gressler_2015_Front.Microbiol_6_184
ESTHER : Gressler_2015_Front.Microbiol_6_184
PubMedSearch : Gressler_2015_Front.Microbiol_6_184
PubMedID: 25852654
Gene_locus related to this paper: aspte-AT1

Title : Terrein biosynthesis in Aspergillus terreus and its impact on phytotoxicity - Zaehle_2014_Chem.Biol_21_719
Author(s) : Zaehle C , Gressler M , Shelest E , Geib E , Hertweck C , Brock M
Ref : Chemical Biology , 21 :719 , 2014
Abstract : Zaehle_2014_Chem.Biol_21_719
ESTHER : Zaehle_2014_Chem.Biol_21_719
PubMedSearch : Zaehle_2014_Chem.Biol_21_719
PubMedID: 24816227
Gene_locus related to this paper: aspte-AT1

Title : The marine-derived fungal metabolite, terrein, inhibits cell proliferation and induces cell cycle arrest in human ovarian cancer cells - Chen_2014_Int.J.Mol.Med_34_1591
Author(s) : Chen YF , Wang SY , Shen H , Yao XF , Zhang FL , Lai D
Ref : Int J Mol Med , 34 :1591 , 2014
Abstract : Chen_2014_Int.J.Mol.Med_34_1591
ESTHER : Chen_2014_Int.J.Mol.Med_34_1591
PubMedSearch : Chen_2014_Int.J.Mol.Med_34_1591
PubMedID: 25318762
Gene_locus related to this paper: aspte-AT1

Title : Terrein induces apoptosis in HeLa human cervical carcinoma cells through p53 and ERK regulation - Porameesanaporn_2013_Oncol.Rep_29_1600
Author(s) : Porameesanaporn Y , Uthaisang-Tanechpongtamb W , Jarintanan F , Jongrungruangchok S , Thanomsub Wongsatayanon B
Ref : Oncol Rep , 29 :1600 , 2013
Abstract : Porameesanaporn_2013_Oncol.Rep_29_1600
ESTHER : Porameesanaporn_2013_Oncol.Rep_29_1600
PubMedSearch : Porameesanaporn_2013_Oncol.Rep_29_1600
PubMedID: 23417151
Gene_locus related to this paper: aspte-AT1

Title : Enhancement of osteoblast biocompatibility on titanium surface with Terrein treatment - Lee_2010_Cell.Biochem.Funct_28_678
Author(s) : Lee YH , Lee NH , Bhattarai G , Oh YT , Yu MK , Yoo ID , Jhee EC , Yi HK
Ref : Cell Biochemistry & Function , 28 :678 , 2010
Abstract : Lee_2010_Cell.Biochem.Funct_28_678
ESTHER : Lee_2010_Cell.Biochem.Funct_28_678
PubMedSearch : Lee_2010_Cell.Biochem.Funct_28_678
PubMedID: 21104936
Gene_locus related to this paper: aspte-AT1

Title : Long-term suppression of tyrosinase by terrein via tyrosinase degradation and its decreased expression - Park_2009_Exp.Dermatol_18_562
Author(s) : Park SH , Kim DS , Lee HK , Kwon SB , Lee S , Ryoo IJ , Kim WG , Yoo ID , Park KC
Ref : Exp Dermatol , 18 :562 , 2009
Abstract : Park_2009_Exp.Dermatol_18_562
ESTHER : Park_2009_Exp.Dermatol_18_562
PubMedSearch : Park_2009_Exp.Dermatol_18_562
PubMedID: 19493001
Gene_locus related to this paper: aspte-AT1

Title : A new terrein glucoside, a novel inhibitor of angiogenin secretion in tumor angiogenesis - Arakawa_2008_J.Antibiot.(Tokyo)_61_442
Author(s) : Arakawa M , Someno T , Kawada M , Ikeda D
Ref : J Antibiot (Tokyo) , 61 :442 , 2008
Abstract : Arakawa_2008_J.Antibiot.(Tokyo)_61_442
ESTHER : Arakawa_2008_J.Antibiot.(Tokyo)_61_442
PubMedSearch : Arakawa_2008_J.Antibiot.(Tokyo)_61_442
PubMedID: 18776656
Gene_locus related to this paper: aspte-AT1

Title : Terrein reduces pulpal inflammation in human dental pulp cells - Lee_2008_J.Endod_34_433
Author(s) : Lee JC , Yu MK , Lee R , Lee YH , Jeon JG , Lee MH , Jhee EC , Yoo ID , Yi HK
Ref : J Endod , 34 :433 , 2008
Abstract : Lee_2008_J.Endod_34_433
ESTHER : Lee_2008_J.Endod_34_433
PubMedSearch : Lee_2008_J.Endod_34_433
PubMedID: 18358890
Gene_locus related to this paper: aspte-AT1

Title : Synthesis and melanin biosynthesis inhibitory activity of (+\/-)-terrein produced by Penicillium sp. 20135 - Lee_2005_Bioorg.Med.Chem.Lett_15_471
Author(s) : Lee S , Kim WG , Kim E , Ryoo IJ , Lee HK , Kim JN , Jung SH , Yoo ID
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :471 , 2005
Abstract : Lee_2005_Bioorg.Med.Chem.Lett_15_471
ESTHER : Lee_2005_Bioorg.Med.Chem.Lett_15_471
PubMedSearch : Lee_2005_Bioorg.Med.Chem.Lett_15_471
PubMedID: 15603975
Gene_locus related to this paper: aspte-AT1

Title : Terrein: a new melanogenesis inhibitor and its mechanism - Park_2004_Cell.Mol.Life.Sci_61_2878
Author(s) : Park SH , Kim DS , Kim WG , Ryoo IJ , Lee DH , Huh CH , Youn SW , Yoo ID , Park KC
Ref : Cell Mol Life Sciences , 61 :2878 , 2004
Abstract : Park_2004_Cell.Mol.Life.Sci_61_2878
ESTHER : Park_2004_Cell.Mol.Life.Sci_61_2878
PubMedSearch : Park_2004_Cell.Mol.Life.Sci_61_2878
PubMedID: 15558216
Gene_locus related to this paper: aspte-AT1