boomi-ACHE3

Boophilus microplus (Cattle tick) putative acetylcholinesterase 3 AChE3 mRNA

Comment

R86Q mutant exhibits 19.2-fold reduced sensitivity to paraoxon. The following mutations were found associated with OP resistant strains, but were also found in susceptible strains and were not characterized biochemically, I48L, I54V, V71A, I77M, S79P, I123M, I492M, T548A, T548Y see: Jyoti et al. 2016

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Boophilus microplus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Protostomia N E > Ecdysozoa N E > Panarthropoda N E > Arthropoda N E > Chelicerata N E > Arachnida N E > Acari N E > Parasitiformes N E > Ixodida N E > Ixodoidea N E > Ixodidae N E > Rhipicephalinae N E > Rhipicephalus [genus] N E > Boophilus N E > Rhipicephalus microplus N E

Molecular evidence

I48L_boomi-ACHE3 I492M_boomi-ACHE3 I54V_boomi-ACHE3 I77M_boomi-ACHE3 R86Q_boomi-ACHE3 S79P_boomi-ACHE3 T548A_boomi-ACHE3 V137I_boomi-ACHE3 V71A_boomi-ACHE3

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

AY267337 GU944960 GU944961 GU944962 GU944963 HM176659

A0A0M3SBL3 A0A0M3SBL4 A0A0M4IU78 A0A0M4J2S1 A0A0M4JMB8 A0A0M4JNN8 A0A0M5K8G0 A0A0M5KCS7 A0A1B2LP87 D7RXY2 E0YCF7 Q6WVH4

Sequence

Peptide

MYSRIVVLLL YGYALRSAHA RCYIFQPGDP IQDTDEKIYL AQPFNVTIPL EAGIPTTAQP ASTGKDQLSL VVPPDDIQSL STTTSRPIST EESPIVETNS GPVQGRRVYA ANRTLYQFVG IPFAEPPVGP LRFRNPVPVK PWSSVYQATK KPFPCLQTDF YINSNVTIPT ANSSEDCLYL NVWTPSRECV LGKFSCVPKT VIVYIYGGTF SFGSSGWDWY DGKEFVARGD VVMVSMNYRV GPMGFFHSGT THSSGNAGLH DQLLAMKWVK QNIRNFGGDP DDVTLVGQSA GAISIGLHLV SPLSKGLFKR IIMESGSPYF RIADNTREGP HKVEKLARAL QCARNDMTIE SHMAEMVECL RKIDGKELLI MSNTIFGVHA LTFFPVFGDD IIPDDPYLMM EQKKFHKADL LIGNNLDEGS YFVFYLFGRA LDLEQAHKIT KYEVDLYVSY CLQMLLRKNV SPIRHYYLSH IGERENIKAL QKAAEAVGDF AIICPTKYFA ESFASMNNKV HYYYFTHRPS FSTWPGWVGP THGDEVFFVM GLPFSSPTIA TDQERELSKL MIETWTTFAK TGKVPDVASK PWPEFTAKNQ VYMELNPKRY TYGRGPNEKN CNFWKSYLKP RGPNEKNCNF WKSYLKP

References (11)

Title : Molecular biology of tick acetylcholinesterases - Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320

Author(s) : Temeyer KB

Ref : Front Biosci (Landmark Ed) , 23 :1320 , 2018

Abstract :

PubMedSearch : Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320

PubMedID: 28930602

Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Multiple mutations in the acetylcholinesterase 3 gene associated with organophosphate resistance in Rhipicephalus (Boophilus) microplus ticks from Punjab, India - Jyoti_2016_Vet.Parasitol_216_108

Author(s) : Jyoti , Singh NK , Singh H , Rath SS

Ref : Vet Parasitol , 216 :108 , 2016

Abstract :

PubMedSearch : Jyoti_2016_Vet.Parasitol_216_108

PubMedID: 26801603

Gene_locus related to this paper: boomi-ACHE3

Title : Inhibitor profile of (n)-tacrines -methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi - Swale_2013_Pestic.Biochem.Physiol_106_

Author(s) : Swale DR , Tong F , Temeyer KB , Li A , Lam PC , Totrov MM , Carlier PR , Perez de Leon AA , Bloomquist JR

Ref : Pesticide Biochemistry and Physiology , 106 : , 2013

Abstract :

PubMedSearch : Swale_2013_Pestic.Biochem.Physiol_106_

PubMedID: 24187393

Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Acetylcholinesterase of Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi: Gene identification, expression, and biochemical properties of recombinant proteins - Temeyer_2013_Pestic.Biochem.Physiol_106_118

Author(s) : Temeyer KB , Olafson PU , Brake DK , Tuckow AP , Li AY , Perez de Leon AA

Ref : Pesticide Biochemistry and Physiology , 106 :118 , 2013

Abstract :

PubMedSearch : Temeyer_2013_Pestic.Biochem.Physiol_106_118

PubMedID:

Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Sequence polymorphism in acetylcholinesterase transcripts and genotyping survey of BmAchE1 in laboratory and Mexican strains of Rhipicephalus (Boophilus) microplus - Temeyer_2012_J.Med.Entomol_49_555

Author(s) : Temeyer KB , Olafson PU , Pruett JH

Ref : Journal of Medical Entomology , 49 :555 , 2012

Abstract :

PubMedSearch : Temeyer_2012_J.Med.Entomol_49_555

PubMedID: 22679862

Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Genetic factors potentially reducing fitness cost of organophosphate insensitive acetylcholinesterase(s) in Rhipicephalus (Boophilus) microplus - Temeyer_2011_Zoosymposia_6_260

Author(s) : Temeyer KB , Tijerina MA , Davey RB , Olafson PU

Ref : Zoosymposia , 6 :260 , 2011

Abstract :

PubMedSearch : Temeyer_2011_Zoosymposia_6_260

PubMedID:

Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Baculovirus expression, biochemical characterization and organophosphate sensitivity of rBmAChE1, rBmAChE2, and rBmAChE3 of Rhipicephalus (Boophilus) microplus - Temeyer_2010_Vet.Parasitol_172_114

Author(s) : Temeyer KB , Pruett JH , Olafson PU

Ref : Vet Parasitol , 172 :114 , 2010

Abstract :

PubMedSearch : Temeyer_2010_Vet.Parasitol_172_114

PubMedID: 20451328

Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Genotyping mutations in BmAChE3: A survey of organophosphate-resistant and -susceptible strains of Rhipicephalus (Boophilus) microplus - Temeyer_2009_J.Med.Entomol_46_1355

Author(s) : Temeyer KB , Olafson PU , Miller RJ

Ref : Journal of Medical Entomology , 46 :1355 , 2009

Abstract :

PubMedSearch : Temeyer_2009_J.Med.Entomol_46_1355

PubMedID: 19960680

Gene_locus related to this paper: boomi-ACHE3

Title : R86Q, a mutation in BmAChE3 yielding a Rhipicephalus microplus organophosphate-insensitive acetylcholinesterase - Temeyer_2007_J.Med.Entomol_44_1013

Author(s) : Temeyer KB , Pruett JH , Olafson PU , Chen AC

Ref : Journal of Medical Entomology , 44 :1013 , 2007

Abstract :

PubMedSearch : Temeyer_2007_J.Med.Entomol_44_1013

PubMedID: 18047200

Gene_locus related to this paper: boomi-ACHE3

Title : Baculovirus expression of BmAChE3, a cDNA encoding an acetylcholinesterase of Boophilus microplus (Acari: Ixodidae) - Temeyer_2006_J.Med.Entomol_43_707

Author(s) : Temeyer KB , Pruett JH , Untalan PM , Chen AC

Ref : Journal of Medical Entomology , 43 :707 , 2006

Abstract :

PubMedSearch : Temeyer_2006_J.Med.Entomol_43_707

PubMedID: 16892628

Gene_locus related to this paper: boomi-ACHE3

Title : Identification of a third Boophilus microplus (Acari: Ixodidae) cDNA presumptively encoding an acetylcholinesterase - Temeyer_2004_J.Med.Entomol_41_259

Author(s) : Temeyer KB , Davey RB , Chen AC

Ref : Journal of Medical Entomology , 41 :259 , 2004

Abstract :

PubMedSearch : Temeyer_2004_J.Med.Entomol_41_259

PubMedID: 15185924

Gene_locus related to this paper: boomi-ACHE3

boomi-ACHE3

Comment

Relationship

Molecular evidence

Mutation (9)

Structure (0)

Kinetic (0)

Disease (0)

Substrate (0)

Inhibitor (0)

Database

Genbank (6)

Interpro (12)

Pfam (12)

UniProt (12)

PIRSF (12)

SUPERFAM (12)

Sequence

Peptide

References (11)

1. Molecular biology of tick acetylcholinesterases - Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320

2. Multiple mutations in the acetylcholinesterase 3 gene associated with organophosphate resistance in Rhipicephalus (Boophilus) microplus ticks from Punjab, India - Jyoti_2016_Vet.Parasitol_216_108

3. Inhibitor profile of (n)-tacrines -methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi - Swale_2013_Pestic.Biochem.Physiol_106_

4. Acetylcholinesterase of Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi: Gene identification, expression, and biochemical properties of recombinant proteins - Temeyer_2013_Pestic.Biochem.Physiol_106_118

5. Sequence polymorphism in acetylcholinesterase transcripts and genotyping survey of BmAchE1 in laboratory and Mexican strains of Rhipicephalus (Boophilus) microplus - Temeyer_2012_J.Med.Entomol_49_555

6. Genetic factors potentially reducing fitness cost of organophosphate insensitive acetylcholinesterase(s) in Rhipicephalus (Boophilus) microplus - Temeyer_2011_Zoosymposia_6_260

7. Baculovirus expression, biochemical characterization and organophosphate sensitivity of rBmAChE1, rBmAChE2, and rBmAChE3 of Rhipicephalus (Boophilus) microplus - Temeyer_2010_Vet.Parasitol_172_114

8. Genotyping mutations in BmAChE3: A survey of organophosphate-resistant and -susceptible strains of Rhipicephalus (Boophilus) microplus - Temeyer_2009_J.Med.Entomol_46_1355

9. R86Q, a mutation in BmAChE3 yielding a Rhipicephalus microplus organophosphate-insensitive acetylcholinesterase - Temeyer_2007_J.Med.Entomol_44_1013

10. Baculovirus expression of BmAChE3, a cDNA encoding an acetylcholinesterase of Boophilus microplus (Acari: Ixodidae) - Temeyer_2006_J.Med.Entomol_43_707

11. Identification of a third Boophilus microplus (Acari: Ixodidae) cDNA presumptively encoding an acetylcholinesterase - Temeyer_2004_J.Med.Entomol_41_259