yeast-FSH1

Saccharomyces cerevisiae (Baker's yeast); Saccharomyces arboricola; Saccharomyces eubayanus family of serine hydrolases 1 (EC 3.1.-.-) in aap1-smf2 intergenic region

Comment

Fsh1p was identified as a lysophospholipase that specifically acts on lysophosphatidylserine (LPS) and impacts the lipid homeostasis in S. cerevisiae (Ramachandran_2021). Other strains: Saccharomyces cerevisiae (YJM789\; AWRI1631\; AWRI796\; VIN 13\; RM11-1a\; Lalvin QA23\; FostersO\; Zymaflore VL3\; JAY291\; FostersB\; Kyokai no. 7 \/ NBRC 101557\; CEN.PK113-7D) (Baker's yeast)Saccharomyces cerevisiae x kudriavzevii (strain VIN7)\; Saccharomyces kudriavzevii (strain ATCC MYA-4449 \/ AS 2.2408 \/ CBS 8840 \/ NBRC 1802 \/ NCYC 2889)\; Saccharomyces arboricola (strain H-6 \/ AS 2.3317 \/ CBS 10644)\; Saccharomyces eubayanus || previously yeast-yhk9

Relationship

Family : FSH1

Block : X

Position in NCBI Life Tree : Saccharomyces cerevisiae

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Saccharomycotina N E > Saccharomycetes N E > Saccharomycetales N E > Saccharomycetaceae N E > Saccharomyces N E > Saccharomyces cerevisiae N E

Molecular evidence

No mutation

No kinetic

No disease

Sequence

Peptide

MTVQIPKLLF LHGFLQNGKV FSEKSSGIRK LLKKANVQCD YIDAPVLLEK KDLPFEMDDE KWQATLDADV NRAWFYHSEI SHELDISEGL KSVVDHIKAN GPYDGIVGFS QGAALSSIIT NKISELVPDH PQFKVSVVIS GYSFTEPDPE HPGELRITEK FRDSFAVKPD MKTKMIFIYG ASDQAVPSVR SKYLYDIYLK AQNGNKEKVL AYEHPGGHMV PNKKDIIRPI VEQITSSLQE ASE

References (12)

Title : FSH1 encodes lysophospholipase activity in Saccharomyces cerevisiae - Ramachandran_2021_Biotechnol.Lett_43_279
Author(s) : Ramachandran G , Chidambaram R , Nachiappan V
Ref : Biotechnol Lett , 43 :279 , 2021
PubMedID: 32920715
Gene_locus related to this paper: yeast-FSH1

Title : Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae - Bun_2020_PLoS.One_15_e0230166
Author(s) : Bun JS , Slack MD , Schemenauer DE , Johnson RJ
Ref : PLoS ONE , 15 :e0230166 , 2020
PubMedID: 32182256
Gene_locus related to this paper: human-OVCA2 , yeast-FSH1

Title : FSH1 overexpression triggers apoptosis in Saccharomyces cerevisiae - Gowsalya_2019_Antonie.Van.Leeuwenhoek_112_1775
Author(s) : Gowsalya R , Ravi C , Arul M , Nachiappan V
Ref : Antonie Van Leeuwenhoek , 112 :1775 , 2019
PubMedID: 31363875
Gene_locus related to this paper: yeast-FSH1

Title : Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118 - Novo_2009_Proc.Natl.Acad.Sci.U.S.A_106_16333
Author(s) : Novo M , Bigey F , Beyne E , Galeote V , Gavory F , Mallet S , Cambon B , Legras JL , Wincker P , Casaregola S , Dequin S
Ref : Proc Natl Acad Sci U S A , 106 :16333 , 2009
PubMedID: 19805302
Gene_locus related to this paper: yeast-AIM2 , yeast-BST1 , yeast-cbpy1 , yeast-cld1 , yeast-dap1 , yeast-dap2 , yeast-dlhh , yeast-ECM18 , yeast-FSH1 , yeast-FSH3 , yeast-ict1 , yeast-kex01 , yeast-MCFS1 , yeast-MCFS2 , yeast-met2 , yeast-mgll , yeast-pdat , yeast-ppme1 , yeast-ROG1 , yeast-SAY1 , yeast-tgl1 , yeast-tgl2 , yeast-yby9 , yeast-YDL109C , yeast-YDR428C , yeast-YDR444W , yeast-yg19 , yeast-yj77 , yeast-yjg8 , yeast-YLL012W , yeast-YLR020C , yeast-YLR118c , yeast-ym60 , yeast-ynl5 , yeast-yo059 , yeast-YPR147C , yeast-hda1

Title : Crystal structure of yeast YHR049W\/FSH1, a member of the serine hydrolase family - Quevillon-Cheruel_2005_Protein.Sci_14_1350
Author(s) : Quevillon-Cheruel S , Leulliot N , Graille M , Hervouet N , Coste F , Benedetti H , Zelwer C , Janin J , van Tilbeurgh H
Ref : Protein Science , 14 :1350 , 2005
PubMedID: 15802654
Gene_locus related to this paper: yeast-FSH1

Title : Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast - Baxter_2004_Mol.Cell.Proteomics_3_209
Author(s) : Baxter SM , Rosenblum JS , Knutson S , Nelson MR , Montimurro JS , Di Gennaro JA , Speir JA , Burbaum JJ , Fetrow JS
Ref : Mol Cell Proteomics , 3 :209 , 2004
PubMedID: 14645503
Gene_locus related to this paper: yeast-FSH1 , yeast-FSH2 , yeast-FSH3 , yeast-mgll , yeast-ppme1 , yeast-YDR428C , yeast-yfd4 , yeast-YLR118c

Title : Global analysis of protein localization in budding yeast - Huh_2003_Nature_425_686
Author(s) : Huh WK , Falvo JV , Gerke LC , Carroll AS , Howson RW , Weissman JS , O'Shea EK
Ref : Nature , 425 :686 , 2003
PubMedID: 14562095
Gene_locus related to this paper: yeast-AIM2 , yeast-BST1 , yeast-ECM18 , yeast-FSH1 , yeast-FSH2 , yeast-mgll , yeast-YDR444W , yeast-YLR118c

Title : Global analysis of protein expression in yeast - Ghaemmaghami_2003_Nature_425_737
Author(s) : Ghaemmaghami S , Huh WK , Bower K , Howson RW , Belle A , Dephoure N , O'Shea EK , Weissman JS
Ref : Nature , 425 :737 , 2003
PubMedID: 14562106
Gene_locus related to this paper: yeast-AIM2 , yeast-ECM18 , yeast-FSH1 , yeast-FSH2 , yeast-MCFS1 , yeast-MCFS2 , yeast-mgll , yeast-YDL109C , yeast-YDR444W , yeast-yfd4 , yeast-yjg8 , yeast-YLR118c , yeast-yo059 , yeast-YPR147C , yeast-hda1 , yeast-ymc0

Title : Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII - Johnston_1994_Science_265_2077
Author(s) : Johnston M , Andrews S , Brinkman R , Cooper J , Ding H , Dover J , Du Z , Favello A , Fulton L , Gattung S , et al.
Ref : Science , 265 :2077 , 1994
PubMedID: 8091229
Gene_locus related to this paper: yeast-FSH1 , yeast-ppme1