penfu-PHAZ
Penicillium funiculosum Polyhydroxybutyrate Depolymerase
Comment
Hisano, T., Kasuya, K., Saito, T., Iwata, T., Miki, K || This is a circularly permuted variant of the alpha\/beta hydrolase fold. Other strains: Talaromyces funiculosus (Fruitlet core rot fungus) (Penicillium funiculosum)\; Penicillium sp. 'occitanis'. Extracellular dPHASCL depolymerises (catalytic domain type 2)
Relationship
Family : Esterase_phb_PHAZ
Block : X
Position in NCBI Life Tree : Penicillium funiculosum
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Trichocomaceae N E > Talaromyces N E > Talaromyces funiculosus N E > cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Trichocomaceae N E > Talaromyces N E > Talaromyces funiculosus N E > cellular organisms N E > Eukaryota N E > Opisthokonta N E > Fungi N E > Dikarya N E > Ascomycota N E > saccharomyceta N E > Pezizomycotina N E > leotiomyceta N E > Eurotiomycetes N E > Eurotiomycetidae N E > Eurotiales N E > Trichocomaceae N E > Talaromyces N E > Talaromyces funiculosus N EMolecular evidence
No mutation
2D80 - Crystal structure of PHB depolymerase from Penicillium funiculosum
2D80 - Crystal structure of PHB depolymerase from Penicillium funiculosum
2D80 - Crystal structure of PHB depolymerase from Penicillium funiculosum
2D81 - Crystal structure of PHB depolymerase from Penicillium funiculosum (S39A) complexed with R3HB trimer
2D81 - Crystal structure of PHB depolymerase from Penicillium funiculosum (S39A) complexed with R3HB trimer
2D81 - Crystal structure of PHB depolymerase from Penicillium funiculosum (S39A) complexed with R3HB trimer
No kinetic
No disease
No inhibitor
Sequence
Peptide
MFDSVKIAWL VALGAAQVAA TALPAFNVNP NSVSVSGLSS GGYMAAQLGV AYSDVFNVGF GVFAGGPYDC ARNQYYTSCM YNGYPSITTP TANMKSWSGN QIASVANLGQ RKIYMWTGSS DTTVGPNVMN QLKAQLGNFD NSANVSYVTT TGAVHTFPTD FNGAGDNSCS LSTSPYISNC NYDGAGAALK WIYGSLNARN TGTLSGSVLS FAQGSYGANG MDTTGYLYVP QSCASGATVC SLHVALHGCL QSYSSIGSRF IQNTGYNKWA DTNNMIILYP QAIPDYTSIH AIWNGGVLSN PNGCWDWVGW YGSNADQIGG VQMAAIVGQV KQIVSGFQG
References (12)
| Title : Directed evolution of hydrolytic enzymes for enhanced biodegradation of spinal surgery scaffolds - Zhao_2025_Int.J.Biol.Macromol__146620 |
| Author(s) : Zhao M , Li C , Li D , Zhang L , Wang Q |
| Ref : Int J Biol Macromol , :146620 , 2025 |
| Abstract : |
| PubMedSearch : Zhao_2025_Int.J.Biol.Macromol__146620 |
| PubMedID: 40816388 |
| Gene_locus related to this paper: 9bact-TtEst2 , canar-LipB , penfu-PHAZ , thefu-q6a0i3 |
| Title : Directed evolution of hydrolytic enzymes for enhanced biodegradation of spinal surgery scaffolds - Zhao_2025_Int.J.Biol.Macromol__146620 |
| Author(s) : Zhao M , Li C , Li D , Zhang L , Wang Q |
| Ref : Int J Biol Macromol , :146620 , 2025 |
| Abstract : |
| PubMedSearch : Zhao_2025_Int.J.Biol.Macromol__146620 |
| PubMedID: 40816388 |
| Gene_locus related to this paper: 9bact-TtEst2 , canar-LipB , penfu-PHAZ , thefu-q6a0i3 |
| Title : Directed evolution of hydrolytic enzymes for enhanced biodegradation of spinal surgery scaffolds - Zhao_2025_Int.J.Biol.Macromol__146620 |
| Author(s) : Zhao M , Li C , Li D , Zhang L , Wang Q |
| Ref : Int J Biol Macromol , :146620 , 2025 |
| Abstract : |
| PubMedSearch : Zhao_2025_Int.J.Biol.Macromol__146620 |
| PubMedID: 40816388 |
| Gene_locus related to this paper: 9bact-TtEst2 , canar-LipB , penfu-PHAZ , thefu-q6a0i3 |
| Title : The crystal structure of polyhydroxybutyrate depolymerase from Penicillium funiculosum provides insights into the recognition and degradation of biopolyesters - Hisano_2006_J.Mol.Biol_356_993 |
| Author(s) : Hisano T , Kasuya K , Tezuka Y , Ishii N , Kobayashi T , Shiraki M , Oroudjev E , Hansma H , Iwata T , Doi Y , Saito T , Miki K |
| Ref : Journal of Molecular Biology , 356 :993 , 2006 |
| Abstract : |
| PubMedSearch : Hisano_2006_J.Mol.Biol_356_993 |
| PubMedID: 16405909 |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : The crystal structure of polyhydroxybutyrate depolymerase from Penicillium funiculosum provides insights into the recognition and degradation of biopolyesters - Hisano_2006_J.Mol.Biol_356_993 |
| Author(s) : Hisano T , Kasuya K , Tezuka Y , Ishii N , Kobayashi T , Shiraki M , Oroudjev E , Hansma H , Iwata T , Doi Y , Saito T , Miki K |
| Ref : Journal of Molecular Biology , 356 :993 , 2006 |
| Abstract : |
| PubMedSearch : Hisano_2006_J.Mol.Biol_356_993 |
| PubMedID: 16405909 |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : The crystal structure of polyhydroxybutyrate depolymerase from Penicillium funiculosum provides insights into the recognition and degradation of biopolyesters - Hisano_2006_J.Mol.Biol_356_993 |
| Author(s) : Hisano T , Kasuya K , Tezuka Y , Ishii N , Kobayashi T , Shiraki M , Oroudjev E , Hansma H , Iwata T , Doi Y , Saito T , Miki K |
| Ref : Journal of Molecular Biology , 356 :993 , 2006 |
| Abstract : |
| PubMedSearch : Hisano_2006_J.Mol.Biol_356_993 |
| PubMedID: 16405909 |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : Properties of a Poly(3-hydroxybutyrate) Depolymerase from Penicillium funiculosum - Miyazaki_2000_J.Polym.Environ_8_175 |
| Author(s) : Miyazaki S , Takahashi K , Shiraki M , Saito T , Tezuka Y , Kasuya KI |
| Ref : J. Polym. Environ , 8 :175 , 2000 |
| Abstract : |
| PubMedSearch : Miyazaki_2000_J.Polym.Environ_8_175 |
| PubMedID: |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : Properties of a Poly(3-hydroxybutyrate) Depolymerase from Penicillium funiculosum - Miyazaki_2000_J.Polym.Environ_8_175 |
| Author(s) : Miyazaki S , Takahashi K , Shiraki M , Saito T , Tezuka Y , Kasuya KI |
| Ref : J. Polym. Environ , 8 :175 , 2000 |
| Abstract : |
| PubMedSearch : Miyazaki_2000_J.Polym.Environ_8_175 |
| PubMedID: |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : Properties of a Poly(3-hydroxybutyrate) Depolymerase from Penicillium funiculosum - Miyazaki_2000_J.Polym.Environ_8_175 |
| Author(s) : Miyazaki S , Takahashi K , Shiraki M , Saito T , Tezuka Y , Kasuya KI |
| Ref : J. Polym. Environ , 8 :175 , 2000 |
| Abstract : |
| PubMedSearch : Miyazaki_2000_J.Polym.Environ_8_175 |
| PubMedID: |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : Extracellular poly(3-hydroxybutyrate) depolymerase from Penicillium funiculosum: general characteristics and active site studies - Brucato_1991_Arch.Biochem.Biophys_290_497 |
| Author(s) : Brucato CL , Wong SS |
| Ref : Archives of Biochemistry & Biophysics , 290 :497 , 1991 |
| Abstract : |
| PubMedSearch : Brucato_1991_Arch.Biochem.Biophys_290_497 |
| PubMedID: 1929416 |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : Extracellular poly(3-hydroxybutyrate) depolymerase from Penicillium funiculosum: general characteristics and active site studies - Brucato_1991_Arch.Biochem.Biophys_290_497 |
| Author(s) : Brucato CL , Wong SS |
| Ref : Archives of Biochemistry & Biophysics , 290 :497 , 1991 |
| Abstract : |
| PubMedSearch : Brucato_1991_Arch.Biochem.Biophys_290_497 |
| PubMedID: 1929416 |
| Gene_locus related to this paper: penfu-PHAZ |
| Title : Extracellular poly(3-hydroxybutyrate) depolymerase from Penicillium funiculosum: general characteristics and active site studies - Brucato_1991_Arch.Biochem.Biophys_290_497 |
| Author(s) : Brucato CL , Wong SS |
| Ref : Archives of Biochemistry & Biophysics , 290 :497 , 1991 |
| Abstract : |
| PubMedSearch : Brucato_1991_Arch.Biochem.Biophys_290_497 |
| PubMedID: 1929416 |
| Gene_locus related to this paper: penfu-PHAZ |