Family: Esterase_phb_PHAZ

Block: X

Parent Family: No family


This is a circularly permuted variant of the alpha/beta hydrolase fold. so could be recognised as a subfamily of Esterase_phb (circular permutation: the first 100 residues are found in c-terminus in Esterase phb)


Interpro : IPR010126 Esterase, PHB depolymerase


Pdoc : No Pdoc

Pfam : PF10503 Esterase_phd

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
2D80 Crystal structure of PHB depolymerase from Penicillium funiculosum penfu-PHAZ
2D81 Crystal structure of PHB depolymerase from Penicillium funiculosum (S39A) complexed with R3HB trimer penfu-PHAZ

Gene_locus Name Species
rhoru-q6ynp7 Rhodospirillum rubrum Poly(3-hydroxyalkanoate) depolymerase phaZ1 Rhodospirillum rubrum
aspfu-q4w9v8 Neosartorya fumigata (strain ATCC MYA-4609 \/ Af293 \/ CBS 101355 \/ FGSC A1100) (Aspergillus fumigatus) Carboxylic ester hydrolase Aspergillus fumigatus Af293
9burk-Q5YEW3 Schlegelella sp. KB1a PHB depolymerase (phaZ) gene Schlegelella sp. KB1a
acisp-Q9ZNH8 Acidovorax sp. TP4 phb depolymerase Acidovorax sp. TP4
calma-PHAZ Caldimonas manganoxidans phb depolymerase precursor Caldimonas manganoxidans
comac-PHAZCAC Comamonas acidovorans (Pseudomonas acidovorans) polyhydroxybutyrate depolymerase Comamonas acidovorans
comte-PHAZ Comamonas testosteroni (Pseudomonas testosteroni), Comamonas sp, poly(3-hydroxybutyrate) depolymerase Comamonas testosteroni
penfu-PHAZ Penicillium funiculosum Polyhydroxybutyrate Depolymerase Penicillium funiculosum
9euro-a0a421cwa8 Aspergillus turcosus Polyhydroxybutyrate Depolymerase CBM1 domain-containing protein Aspergillus turcosus
strex-PHAZ Streptomyces exfoliatus (Streptomyces hydrogenans) poly(3-hydroxybutyrate) depolymerase Streptomyces exfoliatus

Substrate Chemical Nomenclature Proteins
Polybutylene-succinate-co-adipate aspor-cutas    calma-PHAZ    burgl-lipas    sacvd-c7mve8    psea2-s6bc01    burvg-a4jm54    9burk-i3rta9
Polybutylene-succinate aspor-cutas    canar-LipB    fusso-cutas    acide-PBSA    paeam-PLAA    amymu-a0a0h3des9    aspfu-q4w9v8    sacvd-c7mve8    psea2-s6bc01    crysp-Q874E9
Polyethylene-succinate 9zzzz-A0A0G3FEJ8    aspfu-q4w9v8    psecl-LIP1    psecl-LIP2
RB3 (3R)-3-[(3R)-3-[(3R)-3-hydroxybutanoyl]oxybutanoyl]oxybutanoic acid psele-PHAZ7    penfu-PHAZ    aspfu-q4w9v8
PHB poly(3-hydroxybutyrate) psesp-PHBDP1    aspfu-q4w9v8    crysp-Q874E9    alceu-phbc

References (2)

Title : The PHA Depolymerase Engineering Database: A systematic analysis tool for the diverse family of polyhydroxyalkanoate (PHA) depolymerases - Knoll_2009_BMC.Bioinformatics_10_89
Author(s) : Knoll M , Hamm TM , Wagner F , Martinez V , Pleiss J
Ref : BMC Bioinformatics , 10 :89 , 2009
Abstract :
PubMedSearch : Knoll_2009_BMC.Bioinformatics_10_89
PubMedID: 19296857

Title : The crystal structure of polyhydroxybutyrate depolymerase from Penicillium funiculosum provides insights into the recognition and degradation of biopolyesters - Hisano_2006_J.Mol.Biol_356_993
Author(s) : Hisano T , Kasuya K , Tezuka Y , Ishii N , Kobayashi T , Shiraki M , Oroudjev E , Hansma H , Iwata T , Doi Y , Saito T , Miki K
Ref : Journal of Molecular Biology , 356 :993 , 2006
Abstract :
PubMedSearch : Hisano_2006_J.Mol.Biol_356_993
PubMedID: 16405909
Gene_locus related to this paper: penfu-PHAZ