plafa-a0a143zya4

Plasmodium falciparum (isolate 3D7) PF3D7_0818600 BEM46-like protein, putative

Comment

A study of PBLP in the rodent malaria parasite Plasmodium yoelii showed that it has an important role in invasion. Deletion of PBLP affects merozoite formation, sporozoite maturation, and infectivity

Relationship

Family : ABHD13-BEM46

Block : X

Position in NCBI Life Tree : Plasmodium falciparum

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Alveolata N E > Apicomplexa N E > Aconoidasida N E > Haemosporida N E > Plasmodiidae N E > Plasmodium N E > Plasmodium (Laverania) N E > Plasmodium falciparum N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MRIIKYIFFA FIILALFVCA LNTYIYLKQD SFVFSNEFPT VEEKNQTLGE NYEIVTLTTK DNHKFTCWYI KTKDSENKPI MLYFQGNGGY LEKYMNLFNL IIERVDVNIF SCSNRGCGSN IAKPSEEYFY KDAHVYIEYV KTKNPKHLFI FGSSMGAAVA IDTALKQHDH ISGLIVQNAF TSLKELSRYS HPFLNYFLFD YDMIIRSKMD NETKIKNITV PTLFTLSEMD EKVPTSHTRT LFQLSASTNK QLYLSKGGTH PNILKNDDGS YHKAMKKFIV TAISIREKNI QKAVERNPNT PN

References (3)

Title : The Antimalarial Natural Product Salinipostin A Identifies Essential alpha\/beta Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites - Yoo_2020_Cell.Chem.Biol_27_143
Author(s) : Yoo E , Schulze CJ , Stokes BH , Onguka O , Yeo T , Mok S , Gnadig NF , Zhou Y , Kurita K , Foe IT , Terrell SM , Boucher MJ , Cieplak P , Kumpornsin K , Lee MCS , Linington RG , Long JZ , Uhlemann AC , Weerapana E , Fidock DA , Bogyo M
Ref : Cell Chemical Biology , 27 :143 , 2020
PubMedID: 31978322
Gene_locus related to this paper: plaf7-q8ii19 , plafa-a0a143zya4 , plaf7-q8iik5 , plafa-MAL8P1.38 , plafa-PF07.0040 , plafa-PF10.0020 , plafa-PF10.0379 , plafa-PF13.0153

Title : A Plasmodium alpha\/beta-hydrolase modulates the development of invasive stages - Groat-Carmona_2015_Cell.Microbiol_17_1848
Author(s) : Groat-Carmona AM , Kain H , Brownell J , Douglass AN , Aly AS , Kappe SH
Ref : Cell Microbiol , 17 :1848 , 2015
PubMedID: 26118838
Gene_locus related to this paper: plafa-a0a143zya4