plafa-PF07.0040

Plasmodium falciparum (isolate 3D7) PF3D7_0709700 lysophospholipase-like protein, PfPARE Prodrug activation and resistance esterase

Comment

Relationship

Family : Plasmodium_subtelomeric_PST-A

Block : X

Position in NCBI Life Tree : Plasmodium falciparum

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Alveolata N E > Apicomplexa N E > Aconoidasida N E > Haemosporida N E > Plasmodiidae N E > Plasmodium N E > Plasmodium (Laverania) N E > Plasmodium falciparum N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MKSQGGGKIS RKSSTGSSSS RLDGNPKLDS FHNKDGLSLK TYAWTVKNPV GVIIACHGMN SHVRLEYLRH NVEVVNNNKA ILKDGDNYYI YKNSWIEEFN KNGYSFYGID LQSHGQSEGW KGLRTHIRQF DDIVYDFIQY INRIHDMLCL KNKKDNNSSL HDNINNNNNI LPFYIMGLSM GGNVVLRTLQ ILGKSKDNNN KLNIRGCIPL AGMISIDELA TKPSYKYFYI PLAKFLGSFF PSLRLTPGLR FNMFPHMNDI MEFDKFKFKK HVTCRLGYEL LNAINNLNND MDYIPENTPI LFAHSKKDSV CFYGGTLKFY NKLKCLKKEL YTLDDMDHLL PMEPGNERVL KKIITWLAVH TPKQEEQV

References (3)

Title : The Antimalarial Natural Product Salinipostin A Identifies Essential alpha\/beta Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites - Yoo_2020_Cell.Chem.Biol_27_143
Author(s) : Yoo E , Schulze CJ , Stokes BH , Onguka O , Yeo T , Mok S , Gnadig NF , Zhou Y , Kurita K , Foe IT , Terrell SM , Boucher MJ , Cieplak P , Kumpornsin K , Lee MCS , Linington RG , Long JZ , Uhlemann AC , Weerapana E , Fidock DA , Bogyo M
Ref : Cell Chemical Biology , 27 :143 , 2020
PubMedID: 31978322
Gene_locus related to this paper: plaf7-q8ii19 , plafa-a0a143zya4 , plaf7-q8iik5 , plafa-MAL8P1.38 , plafa-PF07.0040 , plafa-PF10.0020 , plafa-PF10.0379 , plafa-PF13.0153

Title : Esterase mutation is a mechanism of resistance to antimalarial compounds - Istvan_2017_Nat.Commun_8_14240
Author(s) : Istvan ES , Mallari JP , Corey VC , Dharia NV , Marshall GR , Winzeler EA , Goldberg DE
Ref : Nat Commun , 8 :14240 , 2017
PubMedID: 28106035
Gene_locus related to this paper: plafa-PF07.0040