plafa-PF10.0020

Plasmodium falciparum (isolate 3D7) PF10_0020 PF3D7_1001600 hypothetical protein exported lipase 2, PfXL2 containing the export element (PEXEL)

Comment

only c-term Pfam A Abhydrolase_5 383 613 || Other strains: Plasmodium falciparum (isolate 3D7)\; Plasmodium falciparum Tanzania (2000708)

Relationship

Family : Plasmodium_subtelomeric_PST-A

Block : X

Position in NCBI Life Tree : Plasmodium falciparum

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Alveolata N E > Apicomplexa N E > Aconoidasida N E > Haemosporida N E > Plasmodiidae N E > Plasmodium N E > Plasmodium (Laverania) N E > Plasmodium falciparum N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

YENSWIQKFN DNQFSFFGID NQSHGLSDGF KDERCFVDDF ENFVLDAVQG LEIFIKELKE KNDVKPIIIM GTSMGGCIAL KMFEYIHKLN KEWKSQIKSL VLISPMISVE RQKSKFTNRI LISIGNILKG FHPLLTLDVK EGGSKYPWIK YDSEIDPFQY SEGLKVGMAS ECVKGADNCM KHNILKYIDK SNVDIMILQS KYDVTVDPTG TVNFMKKMID LYNSKIDKNS NNNKDINDTK NKKNVERTNL KGFNKNKEKK QVSADDKDVS NSSELLDLDN EPCKHLEDYT VLEGNELEPD KHLWKSCNHG YYKNFKKKIK SEKNNKNDSD KEDKKFKHLS AHILNYGAHS LACEPETAES VDILVNWLNN IYP

References (3)

Title : The Antimalarial Natural Product Salinipostin A Identifies Essential alpha\/beta Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites - Yoo_2020_Cell.Chem.Biol_27_143
Author(s) : Yoo E , Schulze CJ , Stokes BH , Onguka O , Yeo T , Mok S , Gnadig NF , Zhou Y , Kurita K , Foe IT , Terrell SM , Boucher MJ , Cieplak P , Kumpornsin K , Lee MCS , Linington RG , Long JZ , Uhlemann AC , Weerapana E , Fidock DA , Bogyo M
Ref : Cell Chemical Biology , 27 :143 , 2020
PubMedID: 31978322
Gene_locus related to this paper: plaf7-q8ii19 , plafa-a0a143zya4 , plaf7-q8iik5 , plafa-MAL8P1.38 , plafa-PF07.0040 , plafa-PF10.0020 , plafa-PF10.0379 , plafa-PF13.0153