(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Metazoa: NE > Eumetazoa: NE > Bilateria: NE > Deuterostomia: NE > Chordata: NE > Craniata: NE > Vertebrata: NE > Gnathostomata: NE > Teleostomi: NE > Euteleostomi: NE > Sarcopterygii: NE > Dipnotetrapodomorpha: NE > Tetrapoda: NE > Amniota: NE > Sauropsida: NE > Sauria: NE > Archelosauria: NE > Archosauria: NE > Dinosauria: NE > Saurischia: NE > Theropoda: NE > Coelurosauria: NE > Aves: NE > Neognathae: NE > Galloanserae: NE > Anseriformes: NE > Anatidae: NE > Anas: NE > Anas platyrhynchos: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MATEKNTLLSLILTAGITALVATGQKAEQPEVVTNYGSVRGYQVKVNAAE RSVNVFLGLPFAKPPVGPLRFSEPQPPEPWKGVRDAASYPPMCLQDKVLG QYFSDAITNRKEKVRLQISEDCLYLNVYTPVSTEEQEKLPVFVWIHGGGL VFGAASSYDGSALAAFDNVVVVTIQYRLGIAGYFSTGDKHARGNWGYLDQ VAALQWIQENIIHFRGDPGSVTIFGESAGGVSVSALVLSPLAKGLFHKAI SESGTAVRILFTDEPEEQAQRIAAAAGCEKSSSAALVECLREKTEAEMEQ ITLKMPPMFISASLDGVFFPKSPRQLLSEKVINAVPYIIGVNNCEFGWIL PRMMKFPEFTEGLEKDVARQVLQSTLALSFKGAPSDIVDLVYNEYIGVAE NRAQVRDGLLDSIADPLFVFSAVEVARHHRDAGNPVYFYEFQHRPSSAAG VVPEFVKADHADEIAFVFGKPFLAGNATEEEAKLSRTVMKYWTNFARNGN PNGEGLVHWPQYDMDERYLEIDLTQKAAKKLKERKMEFWMQLTEQIMSDR RRKHTDL
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its beta-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
Title: Molecular cloning and sequencing of thioesterase B cDNA and stimulation of expression of the thioesterase B gene associated with hormonal induction of peroxisome proliferation Hwang CS, Kolattukudy PE Ref: Journal of Biological Chemistry, 268:14278, 1993 : PubMed
The primary structure deduced from the cDNA of a medium-chain fatty acyl-CoA hydrolase designated thioesterase B from the uropygial gland of mallard duck was determined. A near full-length thioesterase B cDNA was isolated from a duck uropygial gland cDNA library using a 120-base pair polymerase chain reaction probe generated from first strand of cDNA and primers synthesized on the basis of two segments of the enzyme. The nucleotide sequence of this cDNA showed an open reading frame encoding a polypeptide of 557 amino acids including a 25-amino acid leader sequence. It showed little homology to the thioesterase domain of fatty acid synthase and S-acyl fatty acid synthase thioesterase, but showed homology to some esterases such as carboxylesterases. Northern blot showed one major transcript at 2.4 kilobases. The highest level of this transcript was in the uropygial gland, much less in the liver and kidney, and not detectable in other organs. Elevation of thioesterase B transcript level was associated with peroxisome proliferation occurring in the mating season and the increase in transcript level correlated with peroxisome proliferation and synthesis of 3-hydroxyfatty acid diester pheromones resulting from estradiol treatment. This thioesterase may be associated with peroxisome proliferation or peroxisomal metabolism.
