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Gene_locus Report for: human-ABHD17B

Homo sapiens (Human) CGI-67 C9orf77 FAM108B1 protein Abhydrolase domain-containing protein FAM108B1

Comment
ABHD17 proteins are protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization (Lin and Conibear 2015). ABHD17A, 17B, and 17C,are identified as the physiological PSD-95 (the most abundant postsynaptic density scaffolding protein) depalmitoylating enzymes in neurones (Yokoi et al. Q8IY03 Q86YB6 1aa diff + GRRPERGSRLVEDSASAAVLSRPLLPGASARAAQVQS in N-term. otthump00000021455 otthump00000021456


Relationship
Family|ABHD17-depalmitoylase
Block| X
Position in NCBI Life Tree|Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Primates: N E > Haplorrhini: N E > Simiiformes: N E > Catarrhini: N E > Hominoidea: N E > Hominidae: N E > Homininae: N E > Homo: N E > Homo sapiens: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
6 inhibitors (e.g. : ABD957, CID155803778, CID155803782... more)
>3 Genbank links 2 more: AF151825, AL138751, AL671309
1 UniProt : Q5VST6
1 UniProt : Q5VST6
1 Interpro : Q5VST6
1 Prodom : Q5VST6
1 Pfam : Q5VST6
1 PIRSF : Q5VST6
1 SUPERFAM : Q5VST6
1 EntrezGene : 51104
1 SNP : 51104
1 UniGene : 380389
1 HUGO HGNC : 24278
1 Ensembl : ENSG00000107362
Sequence
Graphical view for this peptide sequence: human-ABHD17B
Colored MSA for ABHD17-depalmitoylase (raw)
MNNLSFSELCCLFCCPPLSGEIASKLAFLPPDPTYTLMCDESRTRWTLHL
SERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGN
AVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAW
LALRTRYGIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRV
AFPDTKETYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERC
QRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVQKHKEGK
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MNNLSFSELCCLFCCPPLSGEIASKLAFLPPDPTYTLMCDESRTRWTLHL
SERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGN
AVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAW
LALRTRYGIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRV
AFPDTKETYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERC
QRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVQKHKEGK


References
3 more
    Title: Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization
    Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC
    Ref: Neuron, 94:809, 2017 : PubMed

            

    Title: ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization
    Lin DT, Conibear E
    Ref: Elife, 4:, 2015 : PubMed

            

    Title: Large-scale profiling of protein palmitoylation in mammalian cells
    Martin BR, Cravatt BF
    Ref: Nat Methods, 6:135, 2009 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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