3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin-Cpd6a
AChE IC50 = 20 nM ;selectivity (IC50 BuChE/AChE = 354)
General
Type : Multitarget, Coumarin, Piperidine, Chromen
Chemical_Nomenclature : 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin
Canonical SMILES : N4(CCOC1=CC=C2C(=C1)OC(C(=C2)C3=CC=C(C=C3)N(C)C)=O)CCCCC4
InChI : InChI=1S\/C24H28N2O3\/c1-25(2)20-9-6-18(7-10-20)22-16-19-8-11-21(17-23(19)29-24(22)27)28-15-14-26-12-4-3-5-13-26\/h6-11,16-17H,3-5,12-15H2,1-2H3
InChIKey : AKGBBXJNZKKUEC-UHFFFAOYSA-N
Other name(s) : Compound 6a
phenyl)-7-aminoethoxy-coumarin-Cpd6a.gif)
Target
Families : 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin-Cpd6a ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant - de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| Author(s) : de Souza GA , da Silva SJ , Del Cistia CN , Pitasse-Santos P , Pires LO , Passos YM , Cordeiro Y , Cardoso CM , Castro RN , Sant'Anna CMR , Kummerle AE |
| Ref : J Enzyme Inhib Med Chem , 34 :631 , 2019 |
| Abstract : |
| PubMedSearch : de Souza_2019_J.Enzyme.Inhib.Med.Chem_34_631 |
| PubMedID: 30727776 |