3-allylrhodanine-hydroxyethoxybenzylidene-hydroisoquinoline-Cpd11
Ki 12.70 nM against AChE; 25.11 nM against BChE competitive inhibitor for both
General
Type : Thiazolidine, Thiazole, Sulfur Compound, Isoquinoline
Chemical_Nomenclature : (Z)-3-Allyl-5-{3-[(3,4-dihydroisoquinolin-2(1H)-yl)methyl]-4-hydroxy-5-ethoxybenzylidene}-2-thioxothiazolidin-4-one
Canonical SMILES : C1=CC2=C(C=C1)CC[N+](C2)CC3=CC(=CC(=C3O)OCC)C=C4SC(N(C4=O)CC=C)=S
InChI : InChI=1S\/C25H26N2O3S2\/c1-3-10-27-24(29)22(32-25(27)31)14-17-12-20(23(28)21(13-17)30-4-2)16-26-11-9-18-7-5-6-8-19(18)15-26\/h3,5-8,12-14,28H,1,4,9-11,15-16H2,2H3\/p+1
InChIKey : KCGFSFBDGPWVLG-UHFFFAOYSA-O
Other name(s) : compound 11
Target
Families : 3-allylrhodanine-hydroxyethoxybenzylidene-hydroisoquinoline-Cpd11 ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : New Mannich-type arylidenerhodanines as potent inhibitors of AChE and BChE: synthesis, biological evaluation, cytotoxicity and molecular modeling - Sinan Tokali_2025_RSC.Adv_15_50186 |
| Author(s) : Sinan Tokali F , Senol H , Demir Y , Ulucay O , Ameen M , Shafiq Z |
| Ref : RSC Adv , 15 :50186 , 2025 |
| Abstract : |
| PubMedSearch : Sinan Tokali_2025_RSC.Adv_15_50186 |
| PubMedID: 41403678 |