3-allylrhodanine-hydroxymethoxybenzylidene-hydroisoquinoline-Cpd6
Ki 13.61 nM against AChE; 10.44 nM against BChE competitive inhibitor for both
General
Type : Thiazolidine, Thiazole, Sulfur Compound, Isoquinoline
Chemical_Nomenclature : (Z)-3-Allyl-5-{3-[(3,4-dihydroisoquinolin-2(1H)-yl)methyl]-4-hydroxy-5-methoxybenzylidene}-2-thioxothiazolidin-4-one
Canonical SMILES : C1=CC2=C(C=C1)CC[N+](C2)CC3=CC(=CC(=C3O)OC)C=C4SC(N(C4=O)CC=C)=S
InChI : InChI=1S\/C24H24N2O3S2\/c1-3-9-26-23(28)21(31-24(26)30)13-16-11-19(22(27)20(12-16)29-2)15-25-10-8-17-6-4-5-7-18(17)14-25\/h3-7,11-13,27H,1,8-10,14-15H2,2H3\/p+1
InChIKey : HCQGQEWUAVDLMY-UHFFFAOYSA-O
Other name(s) : Compound 6
Target
Families : 3-allylrhodanine-hydroxymethoxybenzylidene-hydroisoquinoline-Cpd6 ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (1)
| Title : New Mannich-type arylidenerhodanines as potent inhibitors of AChE and BChE: synthesis, biological evaluation, cytotoxicity and molecular modeling - Sinan Tokali_2025_RSC.Adv_15_50186 |
| Author(s) : Sinan Tokali F , Senol H , Demir Y , Ulucay O , Ameen M , Shafiq Z |
| Ref : RSC Adv , 15 :50186 , 2025 |
| Abstract : |
| PubMedSearch : Sinan Tokali_2025_RSC.Adv_15_50186 |
| PubMedID: 41403678 |