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4-thiomorpholinophenyl-thiosemicarbazone-Cpd3l

IC50 nM AChE 11.36 +/- 0.98; BChE 40.45 +/- 7.38; Ki nM AChE 11.15 +/- 0.75; BChE 35.80 +/- 3.87

General

Type : Sulfur Compound, Morpholine, Hydrazide, Urea derivative, Carbothioamide

Chemical_Nomenclature : (E)-N-Benzyl-2-(4-thiomorpholinobenzylidene)hydrazine-1-carbothioamide

Canonical SMILES : C1=CC=CC(=C1)CNC(NN=CC2=CC=C(C=C2)N3CCSCC3)=S

InChI : InChI=1S\/C19H22N4S2\/c24-19(20-14-16-4-2-1-3-5-16)22-21-15-17-6-8-18(9-7-17)23-10-12-25-13-11-23\/h1-9,15H,10-14H2,(H2,20,22,24)

InChIKey : CXVHIEJVYLYWNQ-UHFFFAOYSA-N

Other name(s) : Compound 3l

MW : 370.530

Formula : C19H22N4S2

CAS_number :

PubChem :

UniChem : CXVHIEJVYLYWNQ-UHFFFAOYSA-N

Target

Families : 4-thiomorpholinophenyl-thiosemicarbazone-Cpd3l ligand of proteins in family
BCHE ACHE

Protein :
human-BCHE human-ACHE

References (1)

Title : A series of 4-thiomorpholinophenyl-thiosemicarbazones as cholinesterase inhibitors with anti-neuroblastoma effects - Aftab_2025_Bioorg.Chem_168_109364
Author(s) : Aftab H , Cakir F , Turgut G , Sadeghian N , Alharthy RD , Taslimi P , Sen A , Zaki MEA , Gomha SM , Hussain J , Shafiq Z , Senol H
Ref : Bioorg Chem , 168 :109364 , 2025
Abstract :
PubMedSearch : Aftab_2025_Bioorg.Chem_168_109364
PubMedID: 41389605