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4-thiomorpholinophenyl-thiosemicarbazone-Cpd3n

IC50 nM AChE 12.81 +/- 1.31; BChE 44.54 +/- 4.13; Ki nM AChE 11.25 +/- 1.18 ; BChE 33.42 +/- 2.38

General

Type : Sulfur Compound, Morpholine, Hydrazide, Urea derivative, Carbothioamide

Chemical_Nomenclature : (E)-N-(4-Methylbenzyl)-2-(4-thiomorpholinobenzylidene)hydrazine-1-carbothioamide

Canonical SMILES : C1=C(C=CC(=C1)CNC(NN=CC2=CC=C(C=C2)N3CCSCC3)=S)C

InChI : InChI=1S\/C20H24N4S2\/c1-16-2-4-17(5-3-16)14-21-20(25)23-22-15-18-6-8-19(9-7-18)24-10-12-26-13-11-24\/h2-9,15H,10-14H2,1H3,(H2,21,23,25)

InChIKey : MPTWNAXOQGNQCZ-UHFFFAOYSA-N

Other name(s) : Compound 3n

MW : 384.556

Formula : C20H24N4S2

CAS_number :

PubChem :

UniChem : MPTWNAXOQGNQCZ-UHFFFAOYSA-N

Target

Families : 4-thiomorpholinophenyl-thiosemicarbazone-Cpd3n ligand of proteins in family
BCHE ACHE

Protein :
human-BCHE human-ACHE

References (1)

Title : A series of 4-thiomorpholinophenyl-thiosemicarbazones as cholinesterase inhibitors with anti-neuroblastoma effects - Aftab_2025_Bioorg.Chem_168_109364
Author(s) : Aftab H , Cakir F , Turgut G , Sadeghian N , Alharthy RD , Taslimi P , Sen A , Zaki MEA , Gomha SM , Hussain J , Shafiq Z , Senol H
Ref : Bioorg Chem , 168 :109364 , 2025
Abstract :
PubMedSearch : Aftab_2025_Bioorg.Chem_168_109364
PubMedID: 41389605