AJ-4
GL10a-carbamate || GSK-3 (IC50: 4.7 nM) and AChE (IC50: 2.97 microM
General
Type : Thiadiazol, Sulfur Compound, GSK-3 kinase inhibitor, Carbamate, Multitarget
Chemical_Nomenclature : 4-((2-(3-acrylamido-4-chlorophenyl)-3,5-dioxo-1,2,4-thiadiazolidin-4-yl)methyl) phenyl bis(2-chloroethyl)carbamate
Canonical SMILES : C=CC(NC1=CC(=CC=C1Cl)N2SC(N(C2=O)CC3=CC=C(C=C3)OC(=O)N(CCCl)CCCl)=O)=O
InChI : InChI=1S\/C23H21Cl3N4O5S\/c1-2-20(31)27-19-13-16(5-8-18(19)26)30-21(32)29(23(34)36-30)14-15-3-6-17(7-4-15)35-22(33)28(11-9-24)12-10-25\/h2-8,13H,1,9-12,14H2,(H,27,31)
InChIKey : QBQFDLCQANJLJC-UHFFFAOYSA-N
Other name(s) :
Target
Families : AJ-4 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Single molecule, dual actions: GSK-3beta\/AChE dual inhibition for Alzheimer's disease - Dong_2026_Eur.J.Med.Chem_316_119075 |
| Author(s) : Dong L , Yang J , Meng Y , Yang S , Pan C , Luo F , Long H , Lv S , Gong Y , Xu J , Xiong Y , Dong Y |
| Ref : Eur Journal of Medicinal Chemistry , 316 :119075 , 2026 |
| Abstract : |
| PubMedSearch : Dong_2026_Eur.J.Med.Chem_316_119075 |
| PubMedID: 42320199 |