AM9928
carbamate-based inhibitor AM9928 (hMAGL IC(50) 9 nM) with prolonged pharmacodynamic effects (46 h of target residence time) (ratFAAH IC50 27 nM)
General
Type : Piperazine, Pyridine, Fluoren, Carboxylate, Cyanide
Chemical_Nomenclature : (4-cyano-2-pyridinyl) 4-(9H-fluoren-9-yl)piperazine-1-carboxylate
Canonical SMILES : C1CN(CCN1C2C3=CC=CC=C3C4=CC=CC=C24)C(=O)OC5=NC=CC(=C5)C#N
InChI : InChI=1S\/C24H20N4O2\/c25-16-17-9-10-26-22(15-17)30-24(29)28-13-11-27(12-14-28)23-20-7-3-1-5-18(20)19-6-2-4-8-21(19)23\/h1-10,15,23H,11-14H2
InChIKey : FXNXCSUZLHXTGH-UHFFFAOYSA-N
Other name(s) : AM-9928 || SCHEMBL17460167 || EX-A6370
MW : 396.4
Formula : C24H20N4O2
CAS_number : 1869033-49-7
PubChem : 118679421
UniChem : FXNXCSUZLHXTGH-UHFFFAOYSA-N
Target
Families : AM9928 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Inhibition of triple negative breast cancer-associated inflammation, tumor growth and brain colonization by targeting monoacylglycerol lipase - Benchama_2022_Sci.Rep_12_5328 |
| Author(s) : Benchama O , Tyukhtenko S , Malamas MS , Williams MK , Makriyannis A , Avraham HK |
| Ref : Sci Rep , 12 :5328 , 2022 |
| Abstract : |
| PubMedSearch : Benchama_2022_Sci.Rep_12_5328 |
| PubMedID: 35351947 |
| Gene_locus related to this paper: human-MGLL |