AcACMK
acetyl-alanyl-chloromethyl ketone inhibitor hydrolyzed into acetyl-alanylmethyl-hemiketal (AcAMHK) and bound covalently to the active Ser and His
General
Type : Peptide, ketone, Halo ketone
Chemical_Nomenclature : N-(4-chloro-3-oxobutan-2-yl)acetamide || ~{N}-[(2~{S},3~{S})-3-oxidanylbutan-2-yl]ethanamide
Canonical SMILES : CC(C(=O)CCl)NC(=O)C || C[C@@H]([C@H](C)O)NC(=O)C
InChI : InChI=1S\/C6H10ClNO2\/c1-4(6(10)3-7)8-5(2)9\/h4H,3H2,1-2H3,(H,8,9) || InChI=1S\/C6H13NO2\/c1-4(5(2)8)7-6(3)9\/h4-5,8H,1-3H3,(H,7,9)\/t4-,5-\/m0\/s1
InChIKey : JIXDNUXKVZBCAX-UHFFFAOYSA-N || ZCGNIFXXTKDQRT-WHFBIAKZSA-N
Other name(s) : Ac-DL-Ala-CH2Cl || A1INA
MW : 163.60 || 131.173
Formula : C6H10ClNO2 || C6H13NO2
CAS_number :
PubChem : 104700699
UniChem : JIXDNUXKVZBCAX-UHFFFAOYSA-N, ZCGNIFXXTKDQRT-WHFBIAKZSA-N
Target
Families : AcACMK ligand of proteins in family
ACPH_Peptidase_S9
Structure :
9GNE
Protein :
pig-acph
References (1)
| Title : Ligand binding Pro-miscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase - Kiss-Szeman_2025_Protein.Sci_34_e70320 |
| Author(s) : Kiss-Szeman AJ , Takacs L , Jakli I , Banoczi Z , Hosogi N , Traore DAK , Harmat V , Perczel A , Menyhard DK |
| Ref : Protein Science , 34 :e70320 , 2025 |
| Abstract : |
| PubMedSearch : Kiss-Szeman_2025_Protein.Sci_34_e70320 |
| PubMedID: 41074793 |