pig-acph

Sus scrofa domestica (domestic pig) (EC 3.4.19.1) oxidized protein hydrolase (OPH), acylpeptide-hydrolase (APEH)acylaminoacyl peptidase (AAP)

Comment

Belongs to peptidase family s9C

Relationship

Family : ACPH_Peptidase_S9

Block : X

Position in NCBI Life Tree : Sus scrofa

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Laurasiatheria N E > Cetartiodactyla N E > Suina N E > Suidae N E > Sus N E > Sus scrofa N E

Molecular evidence

No mutation

No kinetic

No disease

Database

Sequence

Peptide

MERQVLLSEP EEAAALYRGL SRQPALSAAC LGPEVTTQYG GRYRTVHTEW TQRDLERMEN IRFCRQYLVF HDGDSVVFAG PAGNSVETRG ELLSRESPSG TMKAVLRKAG GTGTAEEKQF LEVWEKNRKL KSFNLSALEK HGPVYEDDCF GCLSWSHSET HLLYVADKKR PKAESFFQTK ALDVTGSDDE MARTKKPDQA IKGDQFLFYE DWGENMVSKS TPVLCVLDIE SGNISVLEGV PESVSPGQAF WAPGDTGVVF VGWWHEPFRL GIRFCTNRRS ALYYVDLTGG KCELLSDESV AVTSPRLSPD QCRIVYLRFP SLVPHQQCGQ LCLYDWYTRV TSVVVDIVPR QLGEDFSGIY CSLLPLGCWS ADSQRVVFDS PQRSRQDLFA VDTQMGSVTS LTAGGSGGSW KLLTIDRDLM VVQFSTPSVP PSLKVGFLPP AGKEQAVSWV SLEEAEPFPD ISWSIRVLQP PPQQEHVQYA GLDFEAILLQ PSNSPEKTQV PMVVMPHGGP HSSFVTAWML FPAMLCKMGF AVLLVNYRGS TGFGQDSILS LPGNVGHQDV KDVQFAVEQV LQEEHFDAGR VALMGGSHGG FLSCHLIGQY PETYSACVVR NPVINIASMM GSTDIPDWCM VEAGFSYSSD CLPDLSVWAA MLDKSPIKYA PQVKTPLLLM LGQEDRRVPF KQGMEYYRVL KARNVPVRLL LYPKSTHALS EVEVESDSFM NAVLWLCTHL GS

References (6)

Title : A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex - Kiss-Szeman_2022_Chem.Sci_13_14264
Author(s) : Kiss-Szeman AJ , Takacs L , Orgovan Z , Straner P , Jakli I , Schlosser G , Masiulis S , Harmat V , Menyhard DK , Perczel A
Ref : Chem Sci , 13 :14264 , 2022
PubMedID: 36545146
Gene_locus related to this paper: pig-acph

Title : Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad - Kiss-Szeman_2022_Chem.Sci_13_7132
Author(s) : Kiss-Szeman AJ , Straner P , Jakli I , Hosogi N , Harmat V , Menyhard DK , Perczel A
Ref : Chem Sci , 13 :7132 , 2022
PubMedID: 35799812
Gene_locus related to this paper: pig-acph

Title : Structural properties of porcine intestine acylpeptide hydrolase - Durand_2003_J.Protein.Chem_22_183
Author(s) : Durand A , Villard C , Giardina T , Perrier J , Juge N , Puigserver A
Ref : J Protein Chem , 22 :183 , 2003
PubMedID: 12760423
Gene_locus related to this paper: pig-acph

Title : Identification of the catalytic triad residues of porcine liver acylamino acid-releasing enzyme - Mitta_1998_J.Biochem_123_924
Author(s) : Mitta M , Miyagi M , Kato I , Tsunasawa S
Ref : J Biochem , 123 :924 , 1998
PubMedID: 9562627
Gene_locus related to this paper: pig-acph

Title : Complete covalent structure of porcine liver acylamino acid-releasing enzyme and identification of its active site serine residue - Miyagi_1995_J.Biochem_118_771
Author(s) : Miyagi M , Sakiyama F , Kato I , Tsunasawa S
Ref : J Biochem , 118 :771 , 1995
PubMedID: 8576092
Gene_locus related to this paper: pig-acph

Title : The primary structure of porcine liver acylamino acid-releasing enzyme deduced from cDNA sequences - Mitta_1989_J.Biochem_106_548
Author(s) : Mitta M , Asada K , Uchimura Y , Kimizuka F , Kato I , Sakiyama F , Tsunasawa S
Ref : J Biochem , 106 :548 , 1989
PubMedID: 2691504
Gene_locus related to this paper: pig-acph