Alkyne-aminoethyl-phenyl-piperidine-carboxylate
4a-S and 4a-R, showed excellent and selective inhibitory activities against BChE (IC50: 0.051 microM; IC50: 0.059 microM). Compound 4a-S also exhibited selective hMAO-B (IC50 = 0.45 +/- 0.02 microM)
General
Type : Monoamine-oxidase-inhibitor, Multitarget, Piperidine, Alkyne, Carbamate, Propargyl
Chemical_Nomenclature :
Canonical SMILES : C(NC(C1=CC(=CC=C1)OC(=O)N2CCCCC2)C)C#C
InChI : InChI=1S\/C17H22N2O2\/c1-3-10-18-14(2)15-8-7-9-16(13-15)21-17(20)19-11-5-4-6-12-19\/h1,7-9,13-14,18H,4-6,10-12H2,2H3
InChIKey : DPCBLHJKDGGAIV-UHFFFAOYSA-N
Other name(s) : (S)-3-(1-(prop-2-ynylamino)ethyl)phenyl piperidine-1-carboxylate || (R)-3-(1-(prop-2-ynylamino)ethyl)phenyl piperidine-1-carboxylate || Compound 4a-S || Compound 4a-R
Target
Families : Alkyne-aminoethyl-phenyl-piperidine-carboxylate ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Multitarget-directed carbamate and carbamothioate derivatives: Cholinesterase and monoamine oxidase inhibition, anti-beta-amyloid (Abeta) aggregation, antioxidant and blood-brain barrier permeation properties against Alzheimer's disease - Teke_2025_Eur.J.Med.Chem_298_117986 |
| Author(s) : Teke Tuncel S , Erol Gunal S , Demir I , Baysal I , Erdem SS , Telli G , Ucar G , Dogan I , Kelekci NG |
| Ref : Eur Journal of Medicinal Chemistry , 298 :117986 , 2025 |
| Abstract : |
| PubMedSearch : Teke_2025_Eur.J.Med.Chem_298_117986 |
| PubMedID: 40730063 |