BChE-Nrf2modulator-Cpd5c
compounds 5c IC50 BChE 0.27 microM. 5c eliminate ROS accumulation induced by Abeta and upregulated HO-1 and GCLM by promoting the nuclei translocation of Nrf2
General
Type : Nrf2 modulator, Multitarget, Carbamate
Chemical_Nomenclature : (E)-2-methoxy-4(3-((4-nitrophenyl)amino)-3-oxo-1-propenyl) phenyldimethyl carbamate
Canonical SMILES : C1(=C(C=CC(=C1)C=CC(NC2=CC=CC=C2[N+](=O)[O-])=O)OC(=O)N(C)C)OC
InChI : InChI=1S\/C19H19N3O6\/c1-21(2)19(24)28-16-10-8-13(12-17(16)27-3)9-11-18(23)20-14-6-4-5-7-15(14)22(25)26\/h4-12H,1-3H3,(H,20,23)
InChIKey : NTENZTPFWAXHQH-UHFFFAOYSA-N
Other name(s) :
Target
Families : BChE-Nrf2modulator-Cpd5c ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Discovery of ferulic acid carbamate derivatives as dual-targeting agents of BuChE and Nrf2 for Alzheimer's disease - Lao_2026_J.Enzyme.Inhib.Med.Chem_41_2645483 |
| Author(s) : Lao K , Li Y , Xiao Y , Sun Y , Dai Y , Li H , Yang Y , Zhang Y , Wang J , Li W , Gou X , Guan L |
| Ref : J Enzyme Inhib Med Chem , 41 :2645483 , 2026 |
| Abstract : |
| PubMedSearch : Lao_2026_J.Enzyme.Inhib.Med.Chem_41_2645483 |
| PubMedID: 41873153 |