Benzisothiazolinone-Cpd16
IC50 7.8 +/- 1.6 nM
General
Type : Thiazolinone, Sulfur Compound
Chemical_Nomenclature : 2-(3-oxo-1,2-benzothiazol-2-yl)acetamide
Canonical SMILES : C1=CC=C2C(=C1)C(=O)N(S2)CC(=O)N
InChI : InChI=1S\/C9H8N2O2S\/c10-8(12)5-11-9(13)6-3-1-2-4-7(6)14-11\/h1-4H,5H2,(H2,10,12)
InChIKey : DWVOOOVGVIEHIA-UHFFFAOYSA-N
Other name(s) : 3-Oxo-1,2-benzisothiazole-2(3H)-acetamide || EINECS 264-941-0\; 2-(3-Oxo-1,2-benzisothiazolin-2-yl)-acetamide || RefChem:95205 || SCHEMBL12205847
MW : 208.24
Formula : C9H8N2O2S
CAS_number : 64552-26-7
PubChem : 16205182
UniChem : DWVOOOVGVIEHIA-UHFFFAOYSA-N
Target
Families : Benzisothiazolinone-Cpd16 ligand of proteins in family
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (1)
| Title : Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation - Rocca_2026_ChemMedChem_21_e70414 |
| Author(s) : Rocca E , Bedini A , Scalvini L , Galvani F , Castelli R , Sarcone L , Recchia A , Fanini F , Tran A , Rivara S , Spadoni G , Piomelli D , Mor M |
| Ref : ChemMedChem , 21 :e70414 , 2026 |
| Abstract : |
| PubMedSearch : Rocca_2026_ChemMedChem_21_e70414 |
| PubMedID: 42638513 |