| Title : Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation - Rocca_2026_ChemMedChem_21_e70414 |
| Author(s) : Rocca E , Bedini A , Scalvini L , Galvani F , Castelli R , Sarcone L , Recchia A , Fanini F , Tran A , Rivara S , Spadoni G , Piomelli D , Mor M |
| Ref : ChemMedChem , 21 :e70414 , 2026 |
| Abstract : |
| PubMedSearch : Rocca_2026_ChemMedChem_21_e70414 |
| PubMedID: 42638513 |
| Title : Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo - Mugnaini_2024_ACS.Chem.Neurosci__ |
| Author(s) : Mugnaini C , Brizzi A , Paolino M , Scarselli E , Castelli R , de Candia M , Gambacorta N , Nicolotti O , Kostrzewa M , Kumar P , Mahmoud AM , Borgonetti V , Iannotta M , Morace A , Galeotti N , Maione S , Altomare CD , Ligresti A , Corelli F |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : |
| PubMedSearch : Mugnaini_2024_ACS.Chem.Neurosci__ |
| PubMedID: 38372253 |
| Title : Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines - Castelli_2020_J.Med.Chem_63_1261 |
| Author(s) : Castelli R , Scalvini L , Vacondio F , Lodola A , Anselmi M , Vezzosi S , Carmi C , Bassi M , Ferlenghi F , Rivara S , Moller IR , Rand KD , Daglian J , Wei D , Dotsey EY , Ahmed F , Jung KM , Stella N , Singh S , Mor M , Piomelli D |
| Ref : Journal of Medicinal Chemistry , 63 :1261 , 2020 |
| Abstract : |
| PubMedSearch : Castelli_2020_J.Med.Chem_63_1261 |
| PubMedID: 31714779 |