Benzothiazol-morpholino-ethoxy-chromen-Cpd13m
13m IC50 ACHE 0.6 +/- 0.1 nM ; BuChE IC50 of 109.2 +/- 14.7 nM; Competitive inhibitor. Ki 0.12 +/- 0.02 nM for AChE; 47.76 +/- 15.14 nM for BuChE
General
Type : Morpholine, Coumarin, Chromen, Thiazole, Benzothiazol, Sulfur Compound
Chemical_Nomenclature : 3-(benzo[d]thiazol-2-yl)-7-(2-morpholinoethoxy)-2H-chromen-2-one
Canonical SMILES :
InChI :
InChIKey :
Other name(s) : Compound 13m
MW :
Formula :
CAS_number :
PubChem :
UniChem :
Target
Families : Benzothiazol-morpholino-ethoxy-chromen-Cpd13m ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (3)
| Title : Dual inhibition of AChE and BuChE by coumarin-benzothiazole hybrids: potent candidates unveiled through innovative screening and docking studies - Gouvea_2026_Bioorg.Chem_176_109838 |
| Author(s) : Gouvea RG , Bezerra ES , Amaral LG , da Conceicao RA , Pauli FP , Coutinho MS , Amaral AP , De Oliveira PCO , da Silva FC , Teles de Souza AM , de Moraes MC , Forezi L |
| Ref : Bioorg Chem , 176 :109838 , 2026 |
| Abstract : |
| PubMedSearch : Gouvea_2026_Bioorg.Chem_176_109838 |
| PubMedID: 41965189 |
| Title : Dual inhibition of AChE and BuChE by coumarin-benzothiazole hybrids: potent candidates unveiled through innovative screening and docking studies - Gouvea_2026_Bioorg.Chem_176_109838 |
| Author(s) : Gouvea RG , Bezerra ES , Amaral LG , da Conceicao RA , Pauli FP , Coutinho MS , Amaral AP , De Oliveira PCO , da Silva FC , Teles de Souza AM , de Moraes MC , Forezi L |
| Ref : Bioorg Chem , 176 :109838 , 2026 |
| Abstract : |
| PubMedSearch : Gouvea_2026_Bioorg.Chem_176_109838 |
| PubMedID: 41965189 |
| Title : Dual inhibition of AChE and BuChE by coumarin-benzothiazole hybrids: potent candidates unveiled through innovative screening and docking studies - Gouvea_2026_Bioorg.Chem_176_109838 |
| Author(s) : Gouvea RG , Bezerra ES , Amaral LG , da Conceicao RA , Pauli FP , Coutinho MS , Amaral AP , De Oliveira PCO , da Silva FC , Teles de Souza AM , de Moraes MC , Forezi L |
| Ref : Bioorg Chem , 176 :109838 , 2026 |
| Abstract : |
| PubMedSearch : Gouvea_2026_Bioorg.Chem_176_109838 |
| PubMedID: 41965189 |