Benzylpiperidin-methylene-methoxy-dihydro-inden-one
hAChE (IC50 = 43 nM) and BACE-1 (IC50 = 333 nM)
General
Type : Inden, BACE1-inhibitor, Derivative of Donepezil, Multitarget, Piperidine
Chemical_Nomenclature : (E)-2-((1-benzylpiperidin-4-yl)methylene)-5-methoxy-2,3-dihydro-1H-inden-1-one
Canonical SMILES : C1CC(CCN1CC2=CC=CC=C2)C=C4C(C3=CC=C(C=C3C4)OC)=O
InChI : InChI=1S\/C23H25NO2\/c1-26-21-7-8-22-19(15-21)14-20(23(22)25)13-17-9-11-24(12-10-17)16-18-5-3-2-4-6-18\/h2-8,13,15,17H,9-12,14,16H2,1H3
InChIKey : CNIWTTNRVIMZIP-UHFFFAOYSA-N
Other name(s) : compound 20 [Costanzo_2016_ACS.Med.Chem.Lett_7_470]
Target
Families : Benzylpiperidin-methylene-methoxy-dihydro-inden-one ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors - Costanzo_2016_ACS.Med.Chem.Lett_7_470 |
| Author(s) : Costanzo P , Cariati L , Desiderio D , Sgammato R , Lamberti A , Arcone R , Salerno R , Nardi M , Masullo M , Oliverio M |
| Ref : ACS Med Chem Lett , 7 :470 , 2016 |
| Abstract : |
| PubMedSearch : Costanzo_2016_ACS.Med.Chem.Lett_7_470 |
| PubMedID: 27190595 |