Biphenylsulfonyl-indole-thiosemicarbazone-Cpd20
AChE Ki = 54.24 nM; hCA I Ki = 12.75 nM; hCA II Ki = 8.72 nM
General
Type : Indole, Hydrazide, Sulfur Compound, Sulfonamide, Urea derivative, Carbothioamide, Multitarget, Carbonic anhydrase inhibitor
Chemical_Nomenclature : (E)2-({1-[(1,1-Biphenyl)-4-ylsulfonyl]1H-indol-3-yl}methylene)-N-(4-nitrophenyl)hydrazine-1-carbothioamide
Canonical SMILES : C1=CC=CC(=C1)C2=CC=C(C=C2)[S](=O)(=O)[N]3C=C(C4=CC=CC=C34)C=NNC(NC5=CC=C([N+](=O)[O-])C=C5)=S
InChI : InChI=1S\/C28H21N5O4S2\/c34-33(35)24-14-12-23(13-15-24)30-28(38)31-29-18-22-19-32(27-9-5-4-8-26(22)27)39(36,37)25-16-10-21(11-17-25)20-6-2-1-3-7-20\/h1-19H,(H2,30,31,38)
InChIKey : ZLUBLMHSPIUZEC-UHFFFAOYSA-N
Other name(s) : Compound 20
Target
Families : Biphenylsulfonyl-indole-thiosemicarbazone-Cpd20 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (1)
| Title : Design, Synthesis, and Biological Evaluation of Biphenylsulfonyl Indole-Based Thiosemicarbazones as Potential AChE and CA I-II Inhibitors - Yaqoob_2026_Arch.Pharm.(Weinheim)_359_e70315 |
| Author(s) : Yaqoob F , Sadeghian N , Tokali FS , Taslimi P , Alkhedaide AQ , Althobaiti A , Ulucay O , Ibrahim MM , Zaki MEA , Gomha SM , Zhao X , Senol H , Janjua MU , Shafiq Z |
| Ref : Arch Pharm (Weinheim) , 359 :e70315 , 2026 |
| Abstract : |
| PubMedSearch : Yaqoob_2026_Arch.Pharm.(Weinheim)_359_e70315 |
| PubMedID: 42592691 |