Biscarbamate-Cpd16
BChE Ki 0.0119 +/- 0.0030 micro M ; AChE Ki 6.93 +/- 2.04 microM
General
Type : Derivative of Bambuterol, Carbamate, Piperidine
Chemical_Nomenclature : 5-(1-hidroxy-2-(piperidin-1-il)ethyl)-1,3-phenylen bis(piperidine-1)-carboxyilate hydrochloride
Canonical SMILES : C1(=CC(=CC(=C1)C(CN2CCCCC2)O)OC(=O)N3CCCCC3)OC(=O)N4CCCCC4
InChI : InChI=1S\/C25H37N3O5\/c29-23(19-26-10-4-1-5-11-26)20-16-21(32-24(30)27-12-6-2-7-13-27)18-22(17-20)33-25(31)28-14-8-3-9-15-28\/h16-18,23,29H,1-15,19H2
InChIKey : BWDDGVMFEKGIRS-UHFFFAOYSA-N
Other name(s) :
Target
Families : Biscarbamate-Cpd16 ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease - Matosevic_2022_Pharmaceuticals.(Basel)_15_ |
| Author(s) : Matosevic A , Knezevic A , Zandona A , Marakovic N , Kovarik Z , Bosak A |
| Ref : Pharmaceuticals (Basel) , 15 : , 2022 |
| Abstract : |
| PubMedSearch : Matosevic_2022_Pharmaceuticals.(Basel)_15_ |
| PubMedID: 36297332 |