CHDA
IC50 for AChE of 18.55 +/- 5.68 nM
General
Type : Derivative of Tacrine, Acridine, Azepane, anti-Abeta-aggregation
Chemical_Nomenclature : 6-chloro-1,2,3,4,9,10,11,12-octahydro-[1,4]-diazepine-[5,6,7-kl]-acridine Monohydrochloride
Canonical SMILES : C1(=CC3=C2C(=C1)N=C4C(=C2NCCN3)CCCC4)Cl
InChI : InChI=1S\/C15H16ClN3\/c16-9-7-12-14-13(8-9)19-11-4-2-1-3-10(11)15(14)18-6-5-17-12\/h7-8,17-18H,1-6H2
InChIKey : RKCMVBCMTDDHFK-UHFFFAOYSA-N
Other name(s) :
Target
Families : CHDA ligand of proteins in family
ACHE
Protein :
human-ACHE
References (2)
| Title : A Novel Tetrahydroacridine Derivative with Potent Acetylcholinesterase Inhibitory Properties and Dissociative Capability against Abeta42 Fibrils Confirmed by In Vitro Studies - Mojzych_2024_Int.J.Mol.Sci_25_10072 |
| Author(s) : Mojzych I , Zawadzka A , Andrzejewski K , Jampolska M , Bednarikova Z , Gancar M , Gazova Z , Mazur M , Kaczynska K |
| Ref : Int J Mol Sci , 25 :10072 , 2024 |
| Abstract : |
| PubMedSearch : Mojzych_2024_Int.J.Mol.Sci_25_10072 |
| PubMedID: 39337556 |
| Title : A tetrahydroacridine derivative and its conjugate with gold nanoparticles: promising agents for the treatment of Alzheimer's disease - Mojzych_2023_Phys.Chem.Chem.Phys__ |
| Author(s) : Mojzych I , Zawadzka A , Kaczynska K , Wojciechowski P , Zajac D , Chotkowski M , Wiktorska K , Maurin JK , Mazur M |
| Ref : Phys Chem Chem Phys , : , 2023 |
| Abstract : |
| PubMedSearch : Mojzych_2023_Phys.Chem.Chem.Phys__ |
| PubMedID: 37338271 |