Chlorobenzoyl-Methyl-Oxo-Dihydro-Pyrazol-Diazenyl-Benzenesulfonamide-Cpd1f
Ki nM: hCA I 66.81 +/- 5.15; hCA II 62.25 +/- 4.19; AChE 7.45 +/- 0.98 BChE 58.20 +/- 8.11
General
Type : Multitarget, Carbonic anhydrase inhibitor, Pyrazole, Sulfur Compound, Sulfonamide, Diazenyl
Chemical_Nomenclature : 4-([1-(3-Chlorobenzoyl)-3-Methyl-5-Oxo-4,5-Dihydro-1H-Pyrazol-4-Yl]Diazenyl) Benzenesulfonamide
Canonical SMILES : C1=CC(=CC=C1[S](=O)(=O)N)N=NC2C(N(N=C2C)C(C3=CC(=CC=C3)Cl)=O)=O
InChI : InChI=1S\/C17H14ClN5O4S\/c1-10-15(21-20-13-5-7-14(8-6-13)28(19,26)27)17(25)23(22-10)16(24)11-3-2-4-12(18)9-11\/h2-9,15H,1H3,(H2,19,26,27)
InChIKey : LKCQARLOFHZKAL-UHFFFAOYSA-N
Other name(s) : Compound 1f
Target
Families : Chlorobenzoyl-Methyl-Oxo-Dihydro-Pyrazol-Diazenyl-Benzenesulfonamide-Cpd1f ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (3)
| Title : Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME\/T Profiling and Molecular Docking Study - Lolak_2025_Pharmacol.Res.Perspect_13_e70088 |
| Author(s) : Lolak N , Akocak S , Topal M , Kocyigit U M , Isik M , Turkes C , Topal F , Durgun M , Beydemir S |
| Ref : Pharmacol Res Perspect , 13 :e70088 , 2025 |
| Abstract : |
| PubMedSearch : Lolak_2025_Pharmacol.Res.Perspect_13_e70088 |
| PubMedID: 40129107 |
| Title : Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME\/T Profiling and Molecular Docking Study - Lolak_2025_Pharmacol.Res.Perspect_13_e70088 |
| Author(s) : Lolak N , Akocak S , Topal M , Kocyigit U M , Isik M , Turkes C , Topal F , Durgun M , Beydemir S |
| Ref : Pharmacol Res Perspect , 13 :e70088 , 2025 |
| Abstract : |
| PubMedSearch : Lolak_2025_Pharmacol.Res.Perspect_13_e70088 |
| PubMedID: 40129107 |
| Title : Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME\/T Profiling and Molecular Docking Study - Lolak_2025_Pharmacol.Res.Perspect_13_e70088 |
| Author(s) : Lolak N , Akocak S , Topal M , Kocyigit U M , Isik M , Turkes C , Topal F , Durgun M , Beydemir S |
| Ref : Pharmacol Res Perspect , 13 :e70088 , 2025 |
| Abstract : |
| PubMedSearch : Lolak_2025_Pharmacol.Res.Perspect_13_e70088 |
| PubMedID: 40129107 |