Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4f
dual inhibitor of FAAH (not aB-hydrolase) and sEH. Human FAAH IC50 (nM) 15.5; Human sEH IC50 (nM) 2.2; Mouse sEH IC50 (nM) 106.9; Rat sEH IC50 (nM) 1.0. Compound very close to cpd 4d Angelia_2024_Heliyon_10_e32262
General
Type : Piperidine, Sulfur Compound, Sulfonamide, Carboxamide, Multitarget, Isoquinoline
Chemical_Nomenclature : 1-((2-chlorophenyl)sulfonyl)-N-(4-(isoquinolin-7-yl)phenyl)piperidine-4-carboxamide
Canonical SMILES : C1=C(C=CC(=C1)NC(C2CCN(CC2)[S](=O)(=O)C3=C(C=CC=C3)Cl)=O)C4=CC5=C(C=C4)C=CN=C5
InChI : InChI=1S\/C27H24ClN3O3S\/c28-25-3-1-2-4-26(25)35(33,34)31-15-12-21(13-16-31)27(32)30-24-9-7-19(8-10-24)22-6-5-20-11-14-29-18-23(20)17-22\/h1-11,14,17-18,21H,12-13,15-16H2,(H,30,32)
InChIKey : NOGZPTNGQLNSQK-UHFFFAOYSA-N
Other name(s) : Compound 4f
Target
References (1)
| Title : Synthesis and evaluation of isoquinolinyl and pyridinyl-based dual inhibitors of fatty acid amide hydrolase and soluble epoxide hydrolase to alleviate orofacial hyperalgesia in the rat - Carr_2025_Biochem.Biophys.Rep_42_102009 |
| Author(s) : Carr D , Gunari S , Gorostiza G , Mercado M , Pavana L , Duong L , Gomez K , Salinas S , Garcia C , Tsang A , Morisseau C , Hammock BD , Pecic S , Kandasamy R |
| Ref : Biochem Biophys Rep , 42 :102009 , 2025 |
| Abstract : |
| PubMedSearch : Carr_2025_Biochem.Biophys.Rep_42_102009 |
| PubMedID: 40275962 |