Chromene-Phenylpiperazine-Chalcone-Cpd9s
eqBuChE, IC50 = 0.13 microM; monoamine oxidase B MAO-B IC50 = 1.63 microM
General
Type : Chalcone, Monoamine-oxidase-inhibitor, Piperazine, Multitarget, Chromen, anti-Abeta-aggregation, Coumarin
Chemical_Nomenclature : (E)-1-(2-nitrophenyl)-3-(7-(3-(4-phenylpiperazin-1-yl)propoxy)-2H-chromen-3-yl)prop-2-en-1-one
Canonical SMILES : C1=CC=CC(=C1)N2CCN(CC2)CCCOC3=CC=C4C(=C3)OCC(=C4)C=CC(C5=CC=CC=C5[N+](=O)[O-])=O
InChI : InChI=1S\/C31H31N3O5\/c35-30(28-9-4-5-10-29(28)34(36)37)14-11-24-21-25-12-13-27(22-31(25)39-23-24)38-20-6-15-32-16-18-33(19-17-32)26-7-2-1-3-8-26\/h1-5,7-14,21-22H,6,15-20,23H2
InChIKey : OYWOLEVIXMREQG-UHFFFAOYSA-N
Other name(s) : Compound 9s
Target
Families : Chromene-Phenylpiperazine-Chalcone-Cpd9s ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Design, synthesis, and biological evaluation of Chromene-Phenylpiperazine-Chalcone hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease - Liu_2026_Bioorg.Med.Chem_138_118670 |
| Author(s) : Liu Y , Jiang Z , Chen D , He Z , Ning W , Wang S , Guan L |
| Ref : Bioorganic & Medicinal Chemistry , 138 :118670 , 2026 |
| Abstract : |
| PubMedSearch : Liu_2026_Bioorg.Med.Chem_138_118670 |
| PubMedID: 42019114 |