Compound-D1f
IC50 AChE 0.039 +/- 0.001 microM BChE >1000 microM
General
Type : Derivative of Donepezil, Sulfur Compound, Thiazole, Hydrazide, Cyanide, Piperidine
Chemical_Nomenclature : 4-(-3-Methyl-2-((1-(4-(piperidin-1-yl)phenyl)ethylidene)hydrazineylidene)-2,3-dihydrothiazol-4-yl)benzonitrile
Canonical SMILES : C3(=N\/N=C(C)C1=CC=C(C=C1)N2CCCCC2)\/SC=C(N3C)C4=CC=C(C=C4)C#N
InChI : InChI=1S\/C24H25N5S\/c1-18(20-10-12-22(13-11-20)29-14-4-3-5-15-29)26-27-24-28(2)23(17-30-24)21-8-6-19(16-25)7-9-21\/h6-13,17H,3-5,14-15H2,1-2H3\/b26-18?,27-24-
InChIKey : HVGLZZSHKBVXBW-VXEJECSBSA-N
Other name(s) : Compound D1f
Target
Families : Compound-D1f ligand of proteins in family
BCHE
ACHE
Protein :
human-BCHE
human-ACHE
References (3)
| Title : Synthesis and biological evaluation of novel hydrazone derivatives for the treatment of Alzheimer's disease - Ali_2025_RSC.Adv_15_45729 |
| Author(s) : Ali SH , Osmaniye D , Kaplancikli ZA |
| Ref : RSC Adv , 15 :45729 , 2025 |
| Abstract : |
| PubMedSearch : Ali_2025_RSC.Adv_15_45729 |
| PubMedID: 41280213 |
| Title : Synthesis and biological evaluation of novel hydrazone derivatives for the treatment of Alzheimer's disease - Ali_2025_RSC.Adv_15_45729 |
| Author(s) : Ali SH , Osmaniye D , Kaplancikli ZA |
| Ref : RSC Adv , 15 :45729 , 2025 |
| Abstract : |
| PubMedSearch : Ali_2025_RSC.Adv_15_45729 |
| PubMedID: 41280213 |
| Title : Synthesis and biological evaluation of novel hydrazone derivatives for the treatment of Alzheimer's disease - Ali_2025_RSC.Adv_15_45729 |
| Author(s) : Ali SH , Osmaniye D , Kaplancikli ZA |
| Ref : RSC Adv , 15 :45729 , 2025 |
| Abstract : |
| PubMedSearch : Ali_2025_RSC.Adv_15_45729 |
| PubMedID: 41280213 |