Coumarin-phosphazide-Cpd8b
IC 50 ACHE 34.96 +/- 1.36 nM BCHE 133.15 +/- 8.26 nM
General
Type : Multitarget, Coumarin, anti-Abeta-aggregation, Chromen
Chemical_Nomenclature : 4-[[[2-[[(2-oxochromen-4-yl)iminohydrazinylidene]-diphenyl-lambda5-phosphanyl]ethyl-diphenyl-lambda5-phosphanylidene]amino]diazenyl]chromen-2-one
Canonical SMILES : C1=CC=C(C=C1)P(=NN=NC2=CC(=O)OC3=CC=CC=C32)(CCP(=NN=NC4=CC(=O)OC5=CC=CC=C54)(C6=CC=CC=C6)C7=CC=CC=C7)C8=CC=CC=C8
InChI : InChI=1S\/C44H34N6O4P2\/c51-43-31-39(37-25-13-15-27-41(37)53-43)45-47-49-55(33-17-5-1-6-18-33,34-19-7-2-8-20-34)29-30-56(35-21-9-3-10-22-35,36-23-11-4-12-24-36)50-48-46-40-32-44(52)54-42-28-16-14-26-38(40)42\/h1-28,31-32H,29-30H2
InChIKey : KYZDSNSHJIAEDG-UHFFFAOYSA-N
Other name(s) : CHEMBL5200462 || BDBM50595055 || 4,4-((Ethane-1,2-diylbis(diphenylphosphoranylylidene))bis(triaz-1-en-1-yl-3-ylidene))bis(2H-chromen-2-one)
MW : 772.7
Formula : C44H34N6O4P2
CAS_number :
PubChem : 168291301
UniChem : KYZDSNSHJIAEDG-UHFFFAOYSA-N
Target
Families : Coumarin-phosphazide-Cpd8b ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : New phosphazine and phosphazide derivatives as multifunctional ligands targeting acetylcholinesterase and beta-Amyloid aggregation for treatment of Alzheimer's disease - El-Sayed_2019_Bioorg.Chem_95_103499 |
| Author(s) : El-Sayed NF , El-Hussieny M , Ewies EF , Fouad MA , Boulos LS |
| Ref : Bioorg Chem , 95 :103499 , 2019 |
| Abstract : |
| PubMedSearch : El-Sayed_2019_Bioorg.Chem_95_103499 |
| PubMedID: 31838287 |