Cymyl-carbamate-physovenol
General
Type : Derivative of physostigmine-eserine, Carbamate
Chemical_Nomenclature : [(8bS)-4,8b-dimethyl-2,3a-dihydro-1H-furo[2,3-b]indol-7-yl] N-(4-propan-2-ylphenyl)carbamate
Canonical SMILES : CC(C)C1=CC=C(C=C1)NC(=O)OC2=CC3=C(C=C2)N(C4[C@]3(CCO4)C)C
InChI : InChI=1S\/C22H26N2O3\/c1-14(2)15-5-7-16(8-6-15)23-21(25)27-17-9-10-19-18(13-17)22(3)11-12-26-20(22)24(19)4\/h5-10,13-14,20H,11-12H2,1-4H3,(H,23,25)\/t20?,22-\/m0\/s1
InChIKey : NPANUSRHFVUOKM-IAXKEJLGSA-N
Other name(s) : CHEMBL178132 || Physovenine Carbamate 23a || BDBM10619 || (4-Isopropyl-phenyl)-carbamic acid (S)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo[2,3-b]indol-5-yl ester || Cymyl carbamate physovenol
MW : 366.5
Formula : C22H26N2O3
CAS_number :
PubChem : 44388351
UniChem : NPANUSRHFVUOKM-IAXKEJLGSA-N
Target
Families : Cymyl-carbamate-physovenol ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions - Barak_2009_Biochem.J_417_213 |
| Author(s) : Barak D , Ordentlich A , Stein D , Yu QS , Greig NH , Shafferman A |
| Ref : Biochemical Journal , 417 :213 , 2009 |
| Abstract : |
| PubMedSearch : Barak_2009_Biochem.J_417_213 |
| PubMedID: 18729824 |
| Title : Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine - Luo_2006_J.Med.Chem_49_2174 |
| Author(s) : Luo W , Yu QS , Kulkarni SS , Parrish DA , Holloway HW , Tweedie D , Shafferman A , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 49 :2174 , 2006 |
| Abstract : |
| PubMedSearch : Luo_2006_J.Med.Chem_49_2174 |
| PubMedID: 16570913 |
| Title : Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine - Luo_2005_J.Med.Chem_48_986 |
| Author(s) : Luo W , Yu QS , Zhan M , Parrish D , Deschamps JR , Kulkarni SS , Holloway HW , Alley GM , Lahiri DK , Brossi A , Greig NH |
| Ref : Journal of Medicinal Chemistry , 48 :986 , 2005 |
| Abstract : |
| PubMedSearch : Luo_2005_J.Med.Chem_48_986 |
| PubMedID: 15715468 |