DJ-89
General
Type : Urea derivative, Trifluoro, Piperidine
Chemical_Nomenclature :
Canonical SMILES : C1(=CC(=CC(=C1)CC(N2CCC(CC2)NC(NCC3=CC=C(C=C3)OC(F)(F)F)=O)=O)OC)OC || COC1=CC(CC(N2CCC(NC(NCC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)=O)=CC(OC)=C1
InChI : InChI=1S\/C24H28F3N3O5\/c1-33-20-11-17(12-21(14-20)34-2)13-22(31)30-9-7-18(8-10-30)29-23(32)28-15-16-3-5-19(6-4-16)35-24(25,26)27\/h3-6,11-12,14,18H,7-10,13,15H2,1-2H3,(H2,28,29,32)
InChIKey : DDXPKIOYYDTQLO-UHFFFAOYSA-N
Other name(s) : Compound 77
Target
Families : DJ-89 ligand of proteins in family
Epoxide_hydrolase
Structure :
9KPI
Protein :
human-EPHX2
References (1)
| Title : Discovery of Phenylacylpiperidine as Novel sEH Inhibitors through Scaffold Hopping of Natural Stilbene - Ding_2025_J.Med.Chem__ |
| Author(s) : Ding J , Zhu MZ , Du XY , Liu SM , Wang H , Liu XZ , Xie WS , Ma HL , Feng Y , Zhu XH , Liang JH |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Ding_2025_J.Med.Chem__ |
| PubMedID: 40227865 |
| Gene_locus related to this paper: human-EPHX2 |