Demecarium Bromide is the bromide salt form of demecarium, a quaternary ammonium compound and a long-acting cholinesterase inhibitor with parasympathomimetic activity. When used topically, demecarium inactivates both pseudocholinesterase and acetylcholinesterase, thereby preventing acetylcholine breakdown and increasing acetylcholine activity. This causes contraction of the iris sphincter muscle (producing miosis) and the ciliary muscle (affecting the accommodation reflex). In so doing, this agent increases the outflow of the aqueous humor, thereby reducing intraocular pressure.


Type : Trimethylammonium, Bisquaternary, Drug

Chemical_Nomenclature : trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium

Canonical SMILES : CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C

InChI : InChI=1S\/C32H52N4O4\/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8\/h17-22,25-26H,9-16,23-24H2,1-8H3\/q+2


Other name(s) : Humorsol, Frumtosnil, Tonilen, Tosmicil, Tosmilen, demarcarium, UNII-ILP8XJ8R5K, CHEBI:59719, ZINC3875376, DB00944

MW : 716.58

Formula : C32H52Br2N4O4

CAS_number : 56-94-0

PubChem : 5965, 5966


Wikipedia : Demecarium_bromide


Families : Demecarium ligand of proteins in family

References (2)

Title : The effects of topical ocular application of 0.25\% demecarium bromide on serum acetylcholinesterase levels in normal dogs - Ward_2003_Vet.Ophthalmol_6_23
Author(s) : Ward DA , Abney K , Oliver JW
Ref : Vet Ophthalmol , 6 :23 , 2003
PubMedID: 12641839

Title : Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors - Brown_1982_J.Pharmacol.Exp.Ther_223_20
Author(s) : Brown JH , Wetzel GT , Dunlap J
Ref : Journal of Pharmacology & Experimental Therapeutics , 223 :20 , 1982
PubMedID: 6288918