EA-2192
EA 2192, the toxic byproduct of VX hydrolysis
General
Type : Chemical Warfare Agent, Organophosphate, Nerve Agent V-series, Derivative of VX, Sulfur Compound
Chemical_Nomenclature : 2-[di(propan-2-yl)amino]ethylsulfanyl-methylphosphinic acid
Canonical SMILES : CC(C)N(CCSP(=O)(C)O)C(C)C
InChI : InChI=1S\/C9H22NO2PS\/c1-8(2)10(9(3)4)6-7-14-13(5,11)12\/h8-9H,6-7H2,1-5H3,(H,11,12)
InChIKey : UOXJNGFFPMOZDM-UHFFFAOYSA-N
Other name(s) : Diisopropylaminoethyl methyl thiolophosphonate || 5J7SBT85UY || Compound A4 || Phosphonothioic acid, methyl-, S-(2-(bis(1-methylethyl)amino)ethyl) ester
MW : 239.32
Formula : C9H22NO2PS
CAS_number : 73207-98-4
PubChem : 51760
UniChem : UOXJNGFFPMOZDM-UHFFFAOYSA-N
Target
Families : EA-2192 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (9)
| Title : Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase - Clay_2024_Chem.Res.Toxicol__ |
| Author(s) : Clay WK , Buck AK , He Y , Hernandez Sanchez DN , Ward NA , Lear JM , Nguyen KQ , Clark BH , Sapia RJ , Lalisse RF , Sriraman A , Cadieux CL , McElroy CA , Callam CS , Hadad CM |
| Ref : Chemical Research in Toxicology , : , 2024 |
| Abstract : |
| PubMedSearch : Clay_2024_Chem.Res.Toxicol__ |
| PubMedID: 38556765 |
| Title : Effectiveness and reaction networks of H2O2 vapor with NH3 gas for decontamination of the toxic warfare nerve agent, VX on a solid surface - Gon_2015_J.Environ.Sci.Health.A.Tox.Hazard.Subst.Environ.Eng_50_1417 |
| Author(s) : Gon Ryu S , Wan Lee H |
| Ref : J Environ Sci Health A Tox Hazard Subst Environ Eng , 50 :1417 , 2015 |
| Abstract : |
| PubMedSearch : Gon_2015_J.Environ.Sci.Health.A.Tox.Hazard.Subst.Environ.Eng_50_1417 |
| PubMedID: 26327407 |
| Title : Effective, Facile, and Selective Hydrolysis of the Chemical Warfare Agent VX Using Zr6-Based Metal-Organic Frameworks - Moon_2015_Inorg.Chem_54_10829 |
| Author(s) : Moon SY , Wagner GW , Mondloch JE , Peterson GW , DeCoste JB , Hupp JT , Farha OK |
| Ref : Inorg Chem , 54 :10829 , 2015 |
| Abstract : |
| PubMedSearch : Moon_2015_Inorg.Chem_54_10829 |
| PubMedID: 26505999 |
| Title : Determination of S-2-(N,N-diisopropylaminoethyl)- and S-2-(N,N-diethylaminoethyl) methylphosphonothiolate, nerve agent markers, in water samples using strong anion-exchange disk extraction, in vial trimethylsilylation, and gas chromatography-mass spectrometry analysis - Subramaniam_2012_J.Chromatogr.A_1229_86 |
| Author(s) : Subramaniam R , stot C , Juhlin L , Nilsson C , Ostin A |
| Ref : Journal of Chromatography A , 1229 :86 , 2012 |
| Abstract : |
| PubMedSearch : Subramaniam_2012_J.Chromatogr.A_1229_86 |
| PubMedID: 22326187 |
| Title : A study of the kinetics of La3+-promoted methanolysis of S-aryl methylphosphonothioates: possible methodology for decontamination of EA 2192, the toxic byproduct of VX hydrolysis - Dhar_2011_Inorg.Chem_50_3071 |
| Author(s) : Dhar BB , Edwards DR , Brown RS |
| Ref : Inorg Chem , 50 :3071 , 2011 |
| Abstract : |
| PubMedSearch : Dhar_2011_Inorg.Chem_50_3071 |
| PubMedID: 21388185 |
| Title : Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies - Reiter_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_2704 |
| Author(s) : Reiter G , Mikler J , Hill I , Weatherby K , Thiermann H , Worek F |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 879 :2704 , 2011 |
| Abstract : |
| PubMedSearch : Reiter_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_2704 |
| PubMedID: 21862421 |
| Title : Characterization of a phosphodiesterase capable of hydrolyzing EA 2192, the most toxic degradation product of the nerve agent VX - Ghanem_2007_Biochemistry_46_9032 |
| Author(s) : Ghanem E , Li Y , Xu C , Raushel FM |
| Ref : Biochemistry , 46 :9032 , 2007 |
| Abstract : |
| PubMedSearch : Ghanem_2007_Biochemistry_46_9032 |
| PubMedID: 17630782 |
| Title : The sources, fate, and toxicity of chemical warfare agent degradation products - Munro_1999_Environ.Health.Perspect_107_933 |
| Author(s) : Munro NB , Talmage SS , Griffin GD , Waters LC , Watson AP , King JF , Hauschild V |
| Ref : Environmental Health Perspectives , 107 :933 , 1999 |
| Abstract : |
| PubMedSearch : Munro_1999_Environ.Health.Perspect_107_933 |
| PubMedID: 10585900 |
| Title : Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning - Garrigue_1990_Xenobiotica_20_699 |
| Author(s) : Garrigue H , Maurizis JC , Nicolas C , Madelmont JC , Godeneche D , Hulot T , Morge X , Demerseman P , Sentenac-Roumanou H , Veyre A |
| Ref : Xenobiotica , 20 :699 , 1990 |
| Abstract : |
| PubMedSearch : Garrigue_1990_Xenobiotica_20_699 |
| PubMedID: 2146816 |